Immune Modulation by Human Secreted RNases at the Extracellular Space.
Immune Modulation by Human Secreted RNases at the Extracellular Space.
复制标题
DOI：
10.3389/fimmu.2018.01012
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
Boix E
中科院分区：
文献类型：
--
作者：
Lu L;Li J;Moussaoui M;Boix E
核糖核酸酶A超家族是一个脊椎动物特有的蛋白质家族，在人类中包含八个功能成员。这些蛋白质由多种先天免疫细胞分泌，从血细胞到上皮细胞，它们在我们体液中的水平与感染和炎症过程有关。最近的研究认为在细胞外空间的分泌性rna酶起着重要的作用。具有免疫调节和抗菌特性的细胞外核糖核酸酶可以参与多种宿主防御任务，从执行细胞内务管理到维持体液无菌。它们的表达和分泌是对各种损伤刺激的反应。分泌的蛋白质可以针对受损细胞，并促进它们从感染或炎症的焦点移除。在组织损伤后，rnase可以参与清除细胞碎片中的RNA或作为信号分子调节宿主反应并参与组织重塑和修复。我们在这里提供了对人类rna酶的生物学特性及其在健康和疾病中的作用的当前知识的总体观点。综述还包括对其他脊椎动物家族成员和不相关的具有共同作用机制的细胞外rna酶的简要描述。更好地了解RNase的作用机制和对其生理作用的理解将有助于开发新的治疗方法。
The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses eight functional members in humans. The proteins are secreted by diverse innate immune cells, from blood cells to epithelial cells and their levels in our body fluids correlate with infection and inflammation processes. Recent studies ascribe a prominent role to secretory RNases in the extracellular space. Extracellular RNases endowed with immuno-modulatory and antimicrobial properties can participate in a wide variety of host defense tasks, from performing cellular housekeeping to maintaining body fluid sterility. Their expression and secretion are induced in response to a variety of injury stimuli. The secreted proteins can target damaged cells and facilitate their removal from the focus of infection or inflammation. Following tissue damage, RNases can participate in clearing RNA from cellular debris or work as signaling molecules to regulate the host response and contribute to tissue remodeling and repair. We provide here an overall perspective on the current knowledge of human RNases’ biological properties and their role in health and disease. The review also includes a brief description of other vertebrate family members and unrelated extracellular RNases that share common mechanisms of action. A better knowledge of RNase mechanism of actions and an understanding of their physiological roles should facilitate the development of novel therapeutics.
登录
查看更多内容
影响因子：
5
作者：
Ardelt, Wojciech;Ardelt, Barbara;Darzynkiewicz, Zbigniew
通讯作者：
Darzynkiewicz, Zbigniew
影响因子：
13.8
作者：
BENNER, SA;ALLEMANN, RK
通讯作者：
ALLEMANN, RK
DOI：
10.1073/pnas.1222079110
发表时间：
2013-05-14
影响因子：
11.1
作者：
Acquati, Francesco;Lualdi, Marta;Taramelli, Roberto
通讯作者：
Taramelli, Roberto
影响因子：
8
作者：
Bernard, Jamie J.;Gallo, Richard L.
通讯作者：
Gallo, Richard L.
影响因子：
19.6
作者：
通讯作者：
--