Live imaging of stem cells: answering old questions and raising new ones.

Live imaging of stem cells: answering old questions and raising new ones.
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干细胞的实时成像:回答旧问题并提出新问题。

DOI:
10.1016/j.ceb.2016.07.004
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发表时间:
2016-12
影响因子:
7.5
通讯作者:
Cockburn, Katie
Cockburn, Katie
中科院分区:
生物学2区
文献类型:
--
作者:
Park, Sangbum;Greco, Valentina;Cockburn, Katie

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干细胞对于组织维护和损伤修复至关重要,但干细胞生物学的许多方面仍未完全了解。实时成像技术的最新进展使得随着时间的推移,可以直接可视化和跟踪各种组织驻留干细胞在其天然环境中的情况。这些研究的结果有助于解决有关干细胞调节和功能的长期争论,同时也揭示了以前未预料到的现象,为未来的工作提出了新的问题。在这里,我们回顾了这两种类型的最新发现,特别强调干细胞在稳态过程中如何表现以及与其生态位相互作用,以及这些行为如何因受伤而变化。
Stem cells are essential for both tissue maintenance and injury repair, but many aspects of stem cell biology remain incompletely understood. Recent advances in live imaging technology have allowed the direct visualization and tracking of a wide variety of tissue-resident stem cells in their native environments over time. Results from these studies have helped to resolve long-standing debates about stem cell regulation and function while also revealing previously unanticipated phenomena that raise new questions for future work. Here we review recent discoveries of both types, with a particular emphasis on how stem cells behave and interact with their niches during homeostasis, as well as how these behaviours change in response to wounding.
DOI: 10.1002/wdev.151
发表时间: 2014-11
影响因子: --
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