Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study.
Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study.
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DOI：
10.1155/2014/934159
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发表时间：
2014
影响因子：
2
通讯作者：
Magazzù G
中科院分区：
文献类型：
--
作者：
Bramanti E;Cicciù M;Matacena G;Costa S;Magazzù G
乳糜泻 (CD) 患者的症状不典型，常常未被诊断出来。特定的口腔表现是克罗恩病的有效风险指标，因此牙医可以进行早期诊断，从而获得更好的预后。目前还没有研究分析潜在乳糜泻患者出现这些口腔症状的频率。本研究的目的是调查潜在和已确定的乳糜泻儿童的口腔硬组织和软组织病变，并与健康对照进行比较。招募了 50 名已确定的儿童、21 名潜在乳糜泻患者和 54 名对照者，并进行了口腔检查。 CD 患者的总体口腔病变比对照组更常见。已确定乳糜泻患者口腔软组织病变的患病率为 62%，潜在乳糜泻患者为 76.2%，对照组为 12.96%（P < 0.05）。在已确定的乳糜泻患者中观察到临床牙齿延迟萌出的比例为 38%，在潜在乳糜泻患者中的比例为 42.5%，而对照组为 11.11%（P < 0.05）。特定牙釉质缺陷 (SED) 的患病率在确定的乳糜泻中为 48%，在潜在的乳糜泻中为 19%，而对照组为 0%（P < 0.05；OR = 3.923）。 SED 似乎与组织学损伤和绒毛萎缩有遗传相关性。
Patients involved on coeliac disease (CD) have atypical symptoms and often remain undiagnosed. Specific oral manifestations are effective risk indicators of CD and for this reason an early diagnosis with a consequent better prognosis can be performed by the dentist. There are not researches analysing the frequency of these oral manifestations in potential coeliac patients. The aim of this study is to investigate the oral hard and soft tissue lesions in potential and ascertained coeliac children in comparison with healthy controls. 50 ascertained children, 21 potential coeliac patients, and 54 controls were recruited and the oral examination was performed. The overall oral lesions were more frequently present in CD patients than in controls. The prevalence of oral soft tissue lesions was 62% in ascertained coeliac, 76.2% in potential coeliac patients, and 12.96% in controls (P < 0.05). Clinical dental delayed eruption was observed in 38% of the ascertained coeliac and 42.5% of the potential coeliac versus 11.11% of the controls (P < 0.05). The prevalence of specific enamel defects (SED) was 48% in ascertained coeliac and 19% in potential coeliac versus 0% in controls (P < 0.05; OR = 3.923). The SED seem to be genetically related to the histological damage and villous atrophy.
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影响因子：
24.5
作者：
FERGUSON, A;ARRANZ, E;OMAHONY, S
通讯作者：
OMAHONY, S
DOI：
10.1097/mpg.0b013e318181afed
发表时间：
2008-08-01
影响因子：
2.9
作者：
Fasano, A.;Araya, M.;Phillips, A.
通讯作者：
Phillips, A.
DOI：
10.1097/mpg.0b013e31821a23d0
发表时间：
2012-01-01
影响因子：
2.9
作者：
Husby, S.;Koletzko, S.;Zimmer, K. P.
通讯作者：
Zimmer, K. P.
影响因子：
3.8
作者：
MARIANI, P;MAZZILLI, MC;BONAMICO, M
通讯作者：
BONAMICO, M
影响因子：
7.6
作者：
Campisi, G.;Di Liberto, C.;Carroccio, A.
通讯作者：
Carroccio, A.