Alveologenesis: What Governs Secondary Septa Formation.
Alveologenesis: What Governs Secondary Septa Formation.
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DOI：
10.3390/ijms222212107
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发表时间：
2021-11-09
影响因子：
5.6
通讯作者：
Vorotelyak EA
中科院分区：
文献类型：
--
作者：
Rippa AL;Alpeeva EV;Vasiliev AV;Vorotelyak EA
肺泡的简化导致各种肺部病变，如支气管肺发育不良和肺气肿。深入了解肺切除术后继发性隔在发育和再生过程中的出现过程，以及肺泡形成和新肺泡形成的驱动因素的贡献，是有效寻找治疗方法的必要条件。在这篇综述中，我们将肺气体交换单元的形成描述为一个多因素的过程，包括肺泡细胞和肌成纤维细胞的肌动球蛋白细胞骨架的变化、弹性发生、视黄酸信号传导以及肺泡间充质细胞在继发性分离中的作用。关于肺泡形成的机制背景的知识仍然不完整。控制αSMA出现和消耗的机制的表征将允许理解成纤维细胞的生态位是如何变化的。考虑到对肺间充质细胞池进行的大量研究，我们提出了关于间质成纤维细胞的分型及其在肺泡形成和维持中的作用的数据。总的来说，在鉴定肺间质细胞亚群时，必须考虑其发育背景、细胞功能的变化以及基因特征的不稳定性。
The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the contribution of the drivers of alveologenesis and neo-alveolarization is required in an efficient search for therapeutic approaches. In this review, we describe the formation of the gas exchange units of the lung as a multifactorial process, which includes changes in the actomyosin cytoskeleton of alveocytes and myofibroblasts, elastogenesis, retinoic acid signaling, and the contribution of alveolar mesenchymal cells in secondary septation. Knowledge of the mechanistic context of alveologenesis remains incomplete. The characterization of the mechanisms that govern the emergence and depletion of αSMA will allow for an understanding of how the niche of fibroblasts is changing. Taking into account the intense studies that have been performed on the pool of lung mesenchymal cells, we present data on the typing of interstitial fibroblasts and their role in the formation and maintenance of alveoli. On the whole, when identifying cell subpopulations in lung mesenchyme, one has to consider the developmental context, the changing cellular functions, and the lability of gene signatures.
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影响因子：
2.7
作者：
Branchfield K;Li R;Lungova V;Verheyden JM;McCulley D;Sun X
通讯作者：
Sun X
影响因子：
5.5
作者：
Cheong SS;Akram KM;Matellan C;Kim SY;Gaboriau DCA;Hind M;Del Río Hernández AE;Griffiths M;Dean CH
通讯作者：
Dean CH
影响因子：
1.2
作者：
Chamoto, Kenji;Gibney, Barry C.;Lee, Grace S.;Ackermann, Maximilian;Konerding, Moritz A.;Tsuda, Akira;Mentzer, Steven J.
通讯作者：
Mentzer, Steven J.
DOI：
10.1165/rcmb.2012-0030oc
发表时间：
2012-10-01
影响因子：
6.4
作者：
Chen, Leiling;Acciani, Thomas;Perl, Anne-Karina T.
通讯作者：
Perl, Anne-Karina T.
影响因子：
16.6
作者：
Alanis, Denise Martinez;Chang, Daniel R.;Akiyama, Haruhiko;Krasnow, Mark A.;Chen, Jichao
通讯作者：
Chen, Jichao