Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal.
Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal.
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DOI：
10.2337/dc09-0206
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发表时间：
2009-09
期刊：
影响因子：
16.2
通讯作者：
Barrett EJ
中科院分区：
文献类型：
--
作者：
Keske MA;Clerk LH;Price WJ;Jahn LA;Barrett EJ
摄入混合膳食可以增加肌肉毛细血管的血流，并增加健康的年轻瘦人前臂的总血流量。我们研究了这些血管反应是否会因肥胖而减弱。我们给8名中年瘦志愿者和8名肥胖志愿者喂了一顿液体混合餐（480千卡）。饭后2小时内，每隔60分钟测量一次血浆葡萄糖和胰岛素，并评估肱动脉流量和肌肉微血管募集（对比超声）。30min时，瘦组血糖升高（5.1±0.1 vs. 6.7±0.4 mmol/l, P < 0.05），肥胖组血糖升高（5.4±0.2 vs. 6.7±0.4 mmol/l, P < 0.05）。瘦组空腹胰岛素升高（28±4∶241±30 pmol/l, P < 0.05），肥胖组空腹胰岛素升高（65±8 pmol/l, P < 0.001），餐后胰岛素-时间曲线下面积增大（P < 0.05）。瘦肉组在餐后120 min肱动脉流量增加（38±6 vs. 83±16 ml/min, P < 0.05），肥胖组无此现象。瘦肉组肌肉微血管血容量增加120 min(14.4±2.2 vs. 24.4±4.2,P < 0.05)，肥胖组没有。在瘦人身上，混合膳食可以招募肌肉微血管，而肥胖会减弱这种作用。这种受损的血管募集减少了可用的内皮表面，从而可能损害餐后葡萄糖的处理。
Ingestion of a mixed meal recruits flow to muscle capillaries and increases total forearm blood flow in healthy young lean people. We examined whether these vascular responses are blunted by obesity. We fed eight middle-aged lean and eight obese overnight-fasted volunteers a liquid mixed meal (480 kcal). Plasma glucose and insulin were measured every 30 min, and brachial artery flow and muscle microvascular recruitment (contrast ultrasound) were assessed every 60 min over 2 h after the meal. By 30 min, plasma glucose rose in both the lean (5.1 ± 0.1 vs. 6.7 ± 0.4 mmol/l, P < 0.05) and the obese groups (5.4 ± 0.2 vs. 6.7 ± 0.4 mmol/l, P < 0.05). Plasma insulin rose (28 ± 4 vs. 241 ± 30 pmol/l, P < 0.05) by 30 min in the lean group and remained elevated for 2 h. The obese group had higher fasting plasma insulin levels (65 ± 8 pmol/l, P < 0.001) and a greater postmeal area under the insulin-time curve (P < 0.05). Brachial artery flow was increased at 120 min after the meal in the lean group (38 ± 6 vs. 83 ± 16 ml/min, P < 0.05) but not in the obese group. Muscle microvascular blood volume rose by 120 min in the lean group (14.4 ± 2.2 vs. 24.4 ± 4.2 units, P < 0.05) but not in the obese group. A mixed meal recruits muscle microvasculature in lean subjects, and this effect is blunted by obesity. This impaired vascular recruitment lessens the endothelial surface available and may thereby impair postprandial glucose disposal.
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影响因子：
15.9
作者：
DEFRONZO, RA;FERRANNINI, E;FELIG, P
通讯作者：
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通讯作者：
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