Rat ultrasonic vocalizations demonstrate that the motivation to contextually reinstate cocaine-seeking behavior does not necessarily involve a hedonic response.
Rat ultrasonic vocalizations demonstrate that the motivation to contextually reinstate cocaine-seeking behavior does not necessarily involve a hedonic response.
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DOI：
10.1111/adb.12044
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发表时间：
2014-09
影响因子：
3.4
通讯作者：
West MO
中科院分区：
文献类型：
--
作者：
Barker DJ;Bercovicz D;Servilio LC;Simmons SJ;Ma S;Root DH;Pawlak AP;West MO
人类的自我报告通常表明，情绪的变化是药物复吸的主要原因。尽管如此，仍有人认为，在动物模型中，戒断后的药物寻求（即复发/恢复）可能超出了享乐控制。因此，本研究利用大鼠的超声发声，以评估可卡因自我管理（S-A）和可卡因寻求的临床前模型（戒断-恢复模型）中的背景恢复期间的影响。结果表明，虽然受试者有效地恢复药物寻求（杠杆按压）后30天的禁欲，并自发恢复/恢复药物寻求后60天的禁欲，超声发声没有增加超过基线水平在任何恢复会话。这些结果与我们实验室以前的结果和当前的成瘾理论相一致，表明与药物消费弱相关的线索可以激发享乐加工之外的药物寻求行为。
Human self-reports often indicate that changes in mood are a major contributor to drug relapse. Still, arguments have been made that instances of drug-seeking following abstinence in animal models (i.e. relapse/reinstatement) may be outside of hedonic control. Therefore, the present study utilized ultrasonic vocalizations in the rat in order to evaluate affect during cocaine self-administration (S-A) and contextual reinstatement of cocaine-seeking in a pre-clinical model of drug relapse (abstinence-reinstatement model). Results show that while subjects effectively reinstated drug-seeking (lever pressing) following 30 days of abstinence, and spontaneously recovered/reinstated drug seeking following 60 days of abstinence, ultrasonic vocalizations did not increase over baseline levels during either reinstatement session. These results are consistent with previous results from our laboratory and current theories of addiction suggesting that cues that are weakly-associated with drug consumption can motivate drug-seeking behavior that is outside of hedonic processing.
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影响因子：
2.7
作者：
Coffey, Kevin R.;Barker, David J.;Ma, Sisi;Root, David H.;Martinez, Lauren;Horvitz, Jon C.;West, Mark O.
通讯作者：
West, Mark O.
影响因子：
120.7
作者：
BOZARTH, MA;WISE, RA
通讯作者：
WISE, RA
影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
DOI：
10.1111/j.1749-6632.1986.tb27996.x
发表时间：
1986-12-31
影响因子：
5.2
作者：
BARFIELD, RJ;THOMAS, DA
通讯作者：
THOMAS, DA
影响因子：
1.9
作者：
Burgdorf, J;Knutson, B;Ikemoto, S
通讯作者：
Ikemoto, S