Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity.
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity.
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DOI：
10.1038/s41467-021-25985-7
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发表时间：
2021-09-29
影响因子：
16.6
通讯作者：
Rujeni N
中科院分区：
文献类型：
--
作者：
Butera Y;Mukantwari E;Artesi M;Umuringa JD;O'Toole ÁN;Hill V;Rooke S;Hong SL;Dellicour S;Majyambere O;Bontems S;Boujemla B;Quick J;Resende PC;Loman N;Umumararungu E;Kabanda A;Murindahabi MM;Tuyisenge P;Gashegu M;Rwabihama JP;Sindayiheba R;Gikic D;Souopgui J;Ndifon W;Rutayisire R;Gatare S;Mpunga T;Ngamije D;Bours V;Rambaut A;Nsanzimana S;Baele G;Durkin K;Mutesa L;Rujeni N
COVID-19的传播率通常与当地流行的SARS-CoV-2菌株有关。本文描述了从2020年5月至2021年2月在卢旺达流行的菌株中分析的203个SARS-CoV-2全基因组序列。特别是，我们报告了变异分布向目前占主导地位的新兴子谱系a .23.1的转变。此外，我们报告了在基加利国际机场检测的入境旅客中发现的首批B.1.1.7和B.1.351变体卢旺达病例。为了评估来自邻国的病毒引入和本地传播的重要性，我们利用可用的个人旅行历史元数据来提供时空系统地理推断，使我们能够考虑来自未采样地点的感染。我们发现了邻国在向卢旺达播种引种方面的重要作用，包括那些没有基因组序列的国家。我们的研究结果强调了系统的基因组监测和区域合作对于持久抗击COVID-19的重要性。对SARS-CoV-2的基因组监测可以为区域传播动态提供信息，并为公共卫生干预提供信息。在这里，作者对来自卢旺达的约200个样本进行了测序，确定了从2020年5月到2021年2月主要菌株的变化，并推断了地理起源。
COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2. Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from strains circulating in Rwanda from May 2020 to February 2021. In particular, we report a shift in variant distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore, we report the detection of the first Rwandan cases of the B.1.1.7 and B.1.351 variants of concern among incoming travelers tested at Kigali International Airport. To assess the importance of viral introductions from neighboring countries and local transmission, we exploit available individual travel history metadata to inform spatio-temporal phylogeographic inference, enabling us to take into account infections from unsampled locations. We uncover an important role of neighboring countries in seeding introductions into Rwanda, including those from which no genomic sequences were available. Our results highlight the importance of systematic genomic surveillance and regional collaborations for a durable response towards combating COVID-19. Genomic surveillance of SARS-CoV-2 can inform regional transmission dynamics and inform public health interventions. Here, the authors sequence ~200 samples from Rwanda, identify shifts in predominating strains from May 2020 to February 2021, and infer geographic origins.
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影响因子：
10.7
作者：
Dellicour S;Durkin K;Hong SL;Vanmechelen B;Martí-Carreras J;Gill MS;Meex C;Bontems S;André E;Gilbert M;Walker C;Maio N;Faria NR;Hadfield J;Hayette MP;Bours V;Wawina-Bokalanga T;Artesi M;Baele G;Maes P
通讯作者：
Maes P
影响因子：
5.3
作者：
Dudas G;Rambaut A
通讯作者：
Rambaut A
影响因子：
5.3
作者：
Sagulenko P;Puller V;Neher RA
通讯作者：
Neher RA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.8
作者：
Li, Heng
通讯作者：
Li, Heng