Kin recognition and outer membrane exchange (OME) in myxobacteria.

Kin recognition and outer membrane exchange (OME) in myxobacteria.
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亲属识别和外膜交换(OME)。

DOI:
10.1016/j.mib.2020.07.003
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发表时间:
2020-08
影响因子:
5.4
通讯作者:
Wall D
Wall D
中科院分区:
生物学2区
文献类型:
--
作者:
Sah GP;Wall D

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粘细菌具有复杂的社会特征,要求种群高度相关,没有剥削者。为了在种群中富集克隆细胞,他们采用了亲属歧视机制。其中一个关键系统涉及一种多态性细胞表面受体TraA,它通过与邻近粘细菌细胞的同型相互作用来识别自身。最近的研究表明,TraA及其伴侣TraB是流体外膜蛋白,在识别亲属时合并成病灶。病灶的形成导致短暂的膜融合连接和促进合作行为的外膜成分的双向交换。此外,交换了大量的多态性脂蛋白毒素,它们作为自我身份条形码,精确地区分非自我,以组装同质群体。
Myxobacteria conduct complex social traits that requires populations to be highly related and devoid of exploiters. To enrich for clonal cells in populations, they employ kin discrimination mechanisms. One key system involves a polymorphic cell surface receptor, TraA, which recognizes self by homotypic interactions with neighboring myxobacterial cells. Recent studies revealed that TraA and its partner TraB are fluid outer membrane proteins that coalesce into foci upon recognition of kin. The formation of foci leads to transient membrane fusion junctions and the bidirectional exchange of outer membrane components that facilitates cooperative behaviors. Additionally, expansive suites of polymorphic lipoprotein toxins are exchanged, which act as self-identity barcodes that exquisitely discriminate against nonself to assemble homogenous populations.
多态细胞表面受体的分子识别控制细菌中的合作行为。
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发表时间: 2013-11
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影响因子: 4.5
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