Biophysical characterization of local field potential recordings from directional deep brain stimulation electrodes.
Biophysical characterization of local field potential recordings from directional deep brain stimulation electrodes.
复制标题
定向深部脑刺激电极局部场电位记录的生物物理特征。
DOI：
10.1016/j.clinph.2021.01.027
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
McIntyre CC
中科院分区：
文献类型：
--
作者：
Noor MS;McIntyre CC
临床深部脑刺激（DBS）技术的两大进步是引入了局部场电位（LFP）记录功能，以及定向DBS电极的部署。然而，这两种技术并没有在目前的临床DBS设备中进行操作整合。因此，我们评估了使用定向DBS电极记录LFP的理论优势，重点是测量丘脑底核（STN）的β -带活性。我们使用人类STN神经活动的计算模型来模拟LFP记录。该模型由围绕DBS电极的235,280个解剖和电细节详细的STN神经元组成，该电极先前被优化以模拟背外侧STN的β -带同步。然后，我们使用模型系统来比较圆柱形和定向DBS触点的LFP记录，并评估选择不同的触点进行双极记录如何影响LFP测量。该模型预测了定向DBS电极相对于圆柱形DBS电极在STN LFP记录中的两个优势。首先，从定向接触中进行记录可以提供额外的信息，了解STN内同步神经元体积的位置。其次，与圆柱形接触相比，定向接触可以检测到更小体积的同步神经元，我们的模拟预测圆柱形接触的最小半径约为0.5 mm。8触点定向DBS电极（28个可能的双极对）的STN LFP记录可以提供比4触点圆柱形DBS电极（6个可能的双极对）更多的信息，但它们也在分析信号时引入了额外的复杂性。定向电极与能够记录LFP的DBS系统的集成可以提高PD患者同步神经元靶向体积的定位机会。
Two major advances in clinical deep brain stimulation (DBS) technology have been the introduction of local field potential (LFP) recording capabilities, and the deployment of directional DBS electrodes. However, these two technologies are not operationally integrated within current clinical DBS devices. Therefore, we evaluated the theoretical advantages of using directional DBS electrodes for LFP recordings, with a focus on measuring beta-band activity in the subthalamic nucleus (STN). We used a computational model of human STN neural activity to simulate LFP recordings. The model consisted of 235,280 anatomically and electrically detailed STN neurons surrounding the DBS electrode, which was previously optimized to mimic beta-band synchrony in the dorsolateral STN. We then used the model system to compare LFP recordings from cylindrical and directional DBS contacts, and evaluate how the selection of different contacts for bipolar recording affected the LFP measurements. The model predicted two advantages of directional DBS electrodes over cylindrical DBS electrodes for STN LFP recording. First, recording from directional contacts could provide additional insight on the location of a synchronous volume of neurons within the STN. Second, directional contacts could detect a smaller volume of synchronous neurons than cylindrical contacts, which our simulations predicted to be a ~0.5 mm minimum radius. STN LFP recordings from 8-contact directional DBS electrodes (28 possible bipolar pairs) can provide more information than 4-contact cylindrical DBS electrodes (6 possible bipolar pairs), but they also introduce additional complexity in analyzing the signals. Integration of directional electrodes with DBS systems that are capable of LFP recordings could improve opportunities to localize targeted volumes of synchronous neurons in PD patients.
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影响因子：
9.9
作者：
Contarino, M. Fiorella;Bour, Lo J.;Schuurman, P. R.
通讯作者：
Schuurman, P. R.
DOI：
10.1109/tbcas.2018.2880148
发表时间：
2018-12-01
影响因子：
5.1
作者：
Stanslaski, Scott;Herron, Jeffrey;Denison, Timothy
通讯作者：
Denison, Timothy
影响因子：
4.1
作者：
Thompson, John A.;Oukal, Salam;Abosch, Aviva
通讯作者：
Abosch, Aviva
影响因子：
3.7
作者：
Lempka SF;McIntyre CC
通讯作者：
McIntyre CC
影响因子：
7.7
作者：
Bour, L. J.;Lourens, M. A. J.;Contarino, M. F.
通讯作者：
Contarino, M. F.