Optimization of 7-T chemical exchange saturation transfer parameters for validation of glycosaminoglycan and amide proton transfer of fibroglandular breast tissue.
Optimization of 7-T chemical exchange saturation transfer parameters for validation of glycosaminoglycan and amide proton transfer of fibroglandular breast tissue.
复制标题
DOI：
10.1148/radiol.14140762
复制
发表时间：
2015-04
期刊：
影响因子：
19.7
通讯作者：
Smith S
中科院分区：
文献类型：
--
作者：
Dula AN;Dewey BE;Arlinghaus LR;Williams JM;Klomp D;Yankeelov TE;Smith S
The two purposes of this study were to: 1) implement simulation-optimized chemical exchange saturation transfer (CEST) measurements sensitive to amide proton transfer (APT) and glycosaminoglycans (GAG) hydroxyl proton transfer effects in the human breast at 7 Tesla, and 2) determine the reliability of these techniques for evaluation of fibroglandular tissue in the healthy breast as a benchmark for future studies of pathology. All human studies were IRB approved, HIPPA compliant, and included informed consent. The CEST parameters of saturation duration (25 ms) and amplitude (1 μT) were chosen based on simulation-driven optimization for APT contrast with the CEST effect quantified using residuals of a Lorentzian fit. Optimized parameters were implemented at 7 Tesla in ten healthy women in two separate scans to evaluate the reliability of CEST MRI measurements in the breast. CEST z-spectra were acquired over saturation offset frequencies ranging between ±40 ppm using a quadrature unilateral breast coil. The scan-rescan reliability was assessed in terms of the intraclass correlation coefficient, which indicates the ratio of between-subject variation to total variation. Simulations of the Bloch Equations with chemical exchange guided selection of optimal values for pulse duration and amplitude, 25 ms and 1 μT, respectively. Reliability was evaluated using intraclass correlation coefficients (95% confidence intervals) with acceptable results: 0.963 (0.852, 0.991) and 0.903 (0.609, 0.976) for APT and GAG, respectively. We used simulations to derive optimal CEST preparation parameters to elicit maximal CEST contrast in healthy fibroglandular breast tissue due to APT at 7 T. We demonstrate that by using these parameters, obtaining reproducible values for both the amide and hydroxyl protons from of CEST MRI at 7 T is feasible in the human breast
登录
查看更多内容
影响因子：
10.6
作者：
Netsch, T;van Muiswinkel, A
通讯作者：
van Muiswinkel, A
影响因子：
3.3
作者：
Jones, Craig K.;Polders, Daniel;Hua, Jun;Zhu, He;Hoogduin, Hans J.;Zhou, Jinyuan;Luijten, Peter;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.
影响因子：
2.2
作者：
Ward, KM;Aletras, AH;Balaban, RS
通讯作者：
Balaban, RS
影响因子：
2.9
作者：
Klomp, Dennis W. J.;van de Bank, Bart L.;Luijten, Peter R.
通讯作者：
Luijten, Peter R.
影响因子：
3.3
作者：
Zhou, Jinyuan;Blakeley, Jaishri O.;Hua, Jun;Kim, Mina;Laterra, John;Pomper, Martin G.;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.