Diverse roles of LPA signaling in the intestinal epithelium.

Diverse roles of LPA signaling in the intestinal epithelium.
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DOI:
10.1016/j.yexcr.2014.11.013
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发表时间:
2015-05-01
影响因子:
3.7
通讯作者:
Kumar, Ajay
Kumar, Ajay
中科院分区:
医学3区
文献类型:
--
作者:
Yun, C. Chris;Kumar, Ajay

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溶血磷脂酸(LPA)是一种调节多种细胞功能的脂质介质。在结肠直肠癌或炎性肠病患者中已报道了升高的LPA信号传导,并且LPA的致瘤作用已在结肠癌的实验模型中得到证实。然而,新的证据表明LPA信号在上皮伤口愈合和肠道电解质转运调节中的重要性。在这里,我们简要回顾了目前的知识LPA信号在肠道中的生物学作用。
Lysophosphatidic acid (LPA) is a lipid mediator that modulates a wide variety of cellular functions. Elevated LPA signaling has been reported in patients with colorectal cancer or inflammatory bowel diseases, and the tumorigenic role of LPA has been demonstrated in experimental models of colon cancer. However, emerging evidence indicates the importance of LPA signaling in epithelial wound healing and regulation of intestinal electrolyte transport. Here, we briefly review current knowledge of the biological roles of LPA signalling in the intestinal tract.
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