Applying Amide Proton Transfer MR Imaging to Hybrid Brain PET/MR: Concordance with Gadolinium Enhancement and Added Value to [(18)F]FDG PET.
Applying Amide Proton Transfer MR Imaging to Hybrid Brain PET/MR: Concordance with Gadolinium Enhancement and Added Value to [(18)F]FDG PET.
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DOI：
10.1007/s11307-017-1136-0
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发表时间：
2018-06
影响因子：
3.1
通讯作者：
Guo Q
中科院分区：
文献类型：
--
作者：
Sun H;Xin J;Zhou J;Lu Z;Guo Q
采用脑PET/MRI混合成像技术，评估酰胺质子转移（APT）成像与钆增强磁共振成像（MRI）和2-脱氧-2-[18F-]氟-d -葡萄糖（[18F]FDG）正电子发射断层扫描（PET）的诊断一致性和计量相关性。21例受试者接受脑钆增强[18F]FDG PET/MRI前瞻性检查。根据6项诊断标准，比较未增强MRI、增强MRI、APTW和PET的成像准确性。在肿瘤中，进一步采用McNemar试验评估钆增强成像、APT成像与[18F]FDG PET的一致性。通过Pearson相关分析，分析APT成像与PET指标之间的关系。APT成像和钆增强MRI显示出优越且相似的诊断准确性。APTW信号强度与钆增强在19例（100%）中一致，而高[18F]FDG密度仅在12例（63.2%）中显示。在APT成像与PET指标方面，13例高代谢肿瘤与PET指标有显著相关性（P < 0.05），其余6例FDG-avid肿瘤与APT成像指标无相关性[18F]。APT成像可用于提高诊断准确性，无需使用钆螯合物。在脑PET/MR研究中，APT成像可能为[18F]FDG PET评估肿瘤代谢活性提供附加价值。
To evaluate the diagnostic concordance and metric correlations of amide proton transfer (APT) imaging with gadolinium-enhanced magnetic resonance imaging (MRI) and 2-deoxy-2-[18F-]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET), using hybrid brain PET/MRI. Twenty-one subjects underwent brain gadolinium enhanced [18F]FDG PET/MRI prospectively. Imaging accuracy was compared between unenhanced MRI, MRI with enhancement, APT-weighted (APTW) images, and PET based on six diagnostic criteria. Among tumors, the McNemar test was further used for concordance assessment between gadolinium enhanced imaging, APT imaging, and [18F]FDG PET. As well, the relation of metrics between APT imaging and PET was analyzed by the Pearson correlation analysis. APT imaging and gadolinium-enhanced MRI showed superior and similar diagnostic accuracy. APTW signal intensity and gadolinium enhancement were concordant in 19 tumors (100%), while high [18F]FDG avidity was shown in only 12 (63.2%). For the metrics from APT imaging and PET, there was significant correlation for 13 hypermetabolic tumors (P < 0.05) and no correlation for the remaining six [18F]FDG-avid tumors. APT imaging can be used to increase diagnostic accuracy with no need to administer gadolinium chelates. APT imaging may provide an added value to [18F]FDG PET in the evaluation of tumor metabolic activity during brain PET/MR studies.
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