Enhanced port-wine stain lightening achieved with combined treatment of selective photothermolysis and imiquimod.
Enhanced port-wine stain lightening achieved with combined treatment of selective photothermolysis and imiquimod.
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DOI：
10.1016/j.jaad.2011.11.958
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发表时间：
2012-04
影响因子：
13.8
通讯作者：
Kelly, Kristen M.
中科院分区：
文献类型：
--
作者：
Tremaine, Anne Marie;Armstrong, Jennifer;Huang, Yu-Chih;Elkeeb, Leila;Ortiz, Arisa;Harris, Ronald;Choi, Bernard;Kelly, Kristen M.
关键词：
脉冲染料激光是治疗鲜红斑痣胎记的金标准，但需要多次治疗，往往无法完全解决。治疗后血管复发被认为是限制脉冲染料激光治疗鲜红斑痣疗效的一个因素。5%咪喹莫特霜是一种具有抗血管生成作用的免疫调节剂。确定脉冲染料激光后应用5%咪喹莫特乳膏是否改善治疗结果。采用脉冲染料激光治疗鲜红斑痣患者24例，随机分为两组，治疗后分别给予安慰剂和5%咪喹莫特乳膏治疗8周。在基线时对57个葡萄酒色斑部位（每个受试者多个部位）进行色度测量（CIE L*a*B* 颜色空间），并与治疗后8周进行的测量进行比较。测量a* 和ΔE的变化以量化治疗结果。2例受试者出现轻微皮肤刺激。未发现其他不良反应。脉冲染料激光+安慰剂部位（n = 25）的平均Δa* 为0.43，脉冲染料激光+咪喹莫特部位（n = 32）的平均Δ a* 为1.27（p值= 0.0294），表明咪喹莫特的红斑减少更大。脉冲染料激光+安慰剂的平均ΔE为2.59，脉冲染料激光+咪喹莫特的平均ΔE为4.08（p值= 0.0363），再次表明咪喹莫特的颜色改善更大。在单次治疗后评价效果，效果持续时间未知。联合选择性光疗和抗血管生成治疗可提高鲜红斑痣的治疗效果。
Pulsed dye laser is the gold standard for treatment of port wine stain birthmarks but multiple treatments are required and complete resolution is often not achieved. Post-treatment vessel recurrence is thought to be a factor that limits efficacy of pulsed dye laser treatment of port wine stains. Imiquimod 5% cream is an immunomodulator with anti-angiogenic effects. To determine if application of imiquimod 5% cream after pulsed dye laser improves treatment outcome. Healthy patients with port wine stains (n = 24) were treated with pulsed dye laser and then randomized to apply post-treatment placebo or imiquimod 5% cream for 8 weeks. Chromameter measurements (CIE L*a*b* colorspace) for 57 port wine stain sites (multiple sites per subject) were taken at baseline and compared with measurements taken 8 weeks post-treatment. The change in a* and ΔE were measured to quantify treatment outcome. Two subjects developed minor skin irritation. Other adverse effects weren't noted. Average Δa* was 0.43 for pulsed dye laser + placebo sites (n = 25) and 1.27 for pulsed dye laser + imiquimod sites (n = 32) (p value = 0.0294) indicating a greater reduction in erythema with imiquimod. Average ΔE was 2.59 for pulsed dye laser + placebo and 4.08 for pulsed dye laser + imiquimod (p value = 0.0363), again indicating a greater color improvement with imiquimod. Effects were evaluated after a single treatment and duration of effect is unknown. Combined selective photothermolysis and anti-angiogenic therapy may enhance port wine stain treatment efficacy.
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影响因子：
13.8
作者：
Stier, Meghan E.;Glick, Sharon A.;Hirsch, Ranella J.
通讯作者：
Hirsch, Ranella J.
影响因子：
2.4
作者：
Chang, Cheng-Jen;Hsiao, Yen-Chang;Nelson, J. Stuart
通讯作者：
Nelson, J. Stuart
影响因子：
158.5
作者：
van der Horst, CMAM;Koster, PHL;van Gemert, MJC
通讯作者：
van Gemert, MJC
影响因子：
2.4
作者：
Phung, Thuy L.;Oble, Darryl A.;Nelson, J. Stuart
通讯作者：
Nelson, J. Stuart
影响因子：
2.4
作者：
Jung, BJ;Choi, C;Nelson, JS
通讯作者：
Nelson, JS