Plasma arginase-1 as a predictive marker for early transarterial chemoembolization refractoriness in unresectable hepatocellular carcinoma.
Plasma arginase-1 as a predictive marker for early transarterial chemoembolization refractoriness in unresectable hepatocellular carcinoma.
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DOI：
10.3389/fonc.2022.1014653
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发表时间：
2022
影响因子：
4.7
通讯作者：
Li, Hai-Liang
中科院分区：
文献类型：
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作者：
Xia, Wei-Li;Xu, Shi-Jun;Guo, Yuan;Zhao, Xiao-Hui;Hu, Hong-Tao;Zhao, Yan;Yao, Quan-Jun;Zheng, Lin;Zhang, Dong-Yang;Guo, Chen-Yang;Fan, Wei-Jun;Li, Hai-Liang
探讨血浆精氨酸酶-1 （ARG1）与肝细胞癌（HCC）患者早期经动脉化疗栓塞（TACE）难治性的关系，并建立预测早期TACE难治性的形态图。本研究共纳入200例接受TACE治疗的HCC患者，其中120例为训练组，80例为验证组。采用治疗前酶联免疫吸附法检测患者血浆ARG1水平，并采用多变量logistic回归模型确定早期TACE难治性的独立预测因子，在此基础上采用nomogram建立预测模型。多因素logistic分析显示，肿瘤大小（OR= 1.138, 95% CI = 1.006 ~ 1.288, P = 0.041）、多发性肿瘤（OR=4.374, 95% CI = 1.189 ~ 16.089, P = 0.026）、血小板计数（OR= 0.990, 95% CI = 0.980 ~ 0.999, P = 0.036）、血浆ARG1水平（OR= 0.209, 95% CI = 0.079 ~ 0.551, P = 0.002）是早期TACE难治的独立预后因素。训练队列nomogram AUC值为0.786 (95% CI = 0.702 ~ 0.870)，验证集AUC值为0.833 （95% CI = 0.791 ~ 0.875）。决策曲线分析表明该图具有良好的临床应用价值。血浆ARG1高表达与较低的早期TACE难治性发生率相关。基于4个独立预后因素构建的nomogram （nomogram）可以对早期TACE难治性发生率进行个体化预测。
To explore the relationship between plasma arginase-1 (ARG1) and early transarterial chemoembolization (TACE) refractoriness in patients with hepatocellular carcinoma (HCC) and develop nomograms for predicting early TACE refractoriness. A total of 200 patients with HCC, treated with TACE, were included in the study, including 120 in the training set and 80 in the validation set. Pre-treatment enzyme-linked immunosorbent assay was used to detected the plasma ARG1 levels of the patient, and independent predictors of early TACE refractoriness were determined using a multivariate logistic regression model, based on which a predictive model was developed using a nomogram. Risk of early TACE refractoriness was negatively correlated with plasma ARG1 levels, and multivariate logistic analysis showed tumour size (OR = 1.138, 95% CI = 1.006-1.288, P = 0.041), multiple tumors (OR=4.374, 95% CI = 1.189-16.089, P = 0.026), platelet count (OR = 0.990, 95% CI = 0.980-0.999, P = 0.036), and plasma ARG1 levels (OR = 0.209, 95% CI = 0.079-0.551, P = 0.002) to be independent prognostic factors for early TACE refractoriness.The AUC value for the nomogram of the training cohort was 0.786 (95% CI = 0.702–0.870), and the validation set AUC value was 0.833 (95% CI = 0.791-0.875).The decision curve analysis suggested that the nomogram had good clinical utility. High plasma ARG1 expression was associated with a lower incidence of early TACE refractoriness. The nomogram constructed based on four independent prognostic factors could facilitate an individualised prediction of the incidence of early TACE refractoriness.
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影响因子：
--
作者：
You J;Chen W;Chen J;Zheng Q;Dong J;Zhu Y
通讯作者：
Zhu Y
影响因子：
1.5
作者：
Obiorah, Ifeyinwa Emmanuela;Chahine, Oeffrey;Kallakury, Bhaskar
通讯作者：
Kallakury, Bhaskar
影响因子：
2.8
作者：
Chrzanowska, Alicja;Grabon, Wojciech;Baranczyk-Kuzma, Anna
通讯作者：
Baranczyk-Kuzma, Anna
影响因子：
4.7
作者：
Hu HT;Luo JP;Cao GS;Li Z;Jiang M;Guo CY;Yuan H;Yao QJ;Geng X;Park JH;Cheng HT;Jiang L;Ma JL;Zhao Y;Li HL
通讯作者：
Li HL
影响因子：
5.9
作者：
Vesselle, Guillaume;Quirier-Leleu, Camille;Tasu, Jean-Pierre
通讯作者：
Tasu, Jean-Pierre