Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.
Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration.
复制标题
年龄相关性黄斑变性早期阶段微观结构变化与微视野测量之间的纵向关联。
DOI：
10.1167/iovs.15-18294
复制
发表时间：
2016
影响因子：
4.4
通讯作者：
R. Guymer
中科院分区：
文献类型：
--
作者：
Zhichao Wu;David Cunefare;Elizabeth Chiu;C. Luu;L. Ayton;C. Toth;Sina Farsiu;R. Guymer
目的
PURPOSE
To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD.
METHODS
Forty-one AMD eyes underwent microperimetry testing and SD-OCT scans over a 12-month period at 6-month intervals. Microstructural parameters analyzed include the retinal pigment epithelium-drusen complex (RPEDC) layer thickness, number of hyperreflective foci (HF) and their inner retinal migration (represented by a weighted axial distribution score; AxD), and the number of atrophic areas.
RESULTS
Microperimetric sensitivity was 0.29 dB (95% confidence interval [CI] = -0.38 to -0.20 dB, P < 0.001) and 0.13 dB (95% CI = -0.22 to -0.03 dB, P = 0.008) lower in each sector for every 10-μm higher RPEDC layer thickness and 1-HF present, but was not associated with the AxD score or the number of atrophic areas present (P ≤ 0.464). However, each 10-μm greater RPEDC layer thickness and 1-HF present was not independently associated with a further decline in sensitivity (-0.08 dB/year, 95% CI = -0.24 to 0.07 dB/year, P = 0.288 and 0.09 dB/year, 95% CI = -0.06 to 0.24 dB/year, P = 0.242, respectively) over time when accounting for the association between RPEDC layer thickness and number of HF with microperimetric sensitivity.
CONCLUSIONS
Longitudinal changes in mesopic visual function measured on microperimetry paralleled changes in the microstructural changes over a 12-month time frame, without any changes occurring independent of the associations between structure and function alone.
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影响因子：
13.7
作者：
Owsley C;McGwin G Jr;Clark ME;Jackson GR;Callahan MA;Kline LB;Witherspoon CD;Curcio CA
通讯作者：
Curcio CA
影响因子：
4.4
作者：
Jain N;Farsiu S;Khanifar AA;Bearelly S;Smith RT;Izatt JA;Toth CA
通讯作者：
Toth CA
影响因子：
4.4
作者：
Acton, Jennifer H.;Smith, R. Theodore;Greenstein, Vivienne C.
通讯作者：
Greenstein, Vivienne C.
影响因子：
13.7
作者：
Christenbury JG;Folgar FA;O'Connell RV;Chiu SJ;Farsiu S;Toth CA;Age-related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
通讯作者：
Age-related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
影响因子：
4.4
作者：
Rickman, Catherine Bowes;Farsiu, Sina;Klingeborn, Mikael
通讯作者：
Klingeborn, Mikael