Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.
Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.
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DOI：
10.1167/iovs.09-4962
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发表时间：
2010-10
影响因子：
4.4
通讯作者：
Toth CA
中科院分区：
文献类型：
--
作者：
Jain N;Farsiu S;Khanifar AA;Bearelly S;Smith RT;Izatt JA;Toth CA
光谱域光学相干断层扫描（SD OCT）可用于有效测量年龄相关性黄斑变性（AMD）患者的drusen。我们评估了从SD OCT上半自动分割的病灶区域与从数字彩色眼底照片（CFP）中识别的病灶区域。采用数字CFP和SD oct对12只患有非血管性AMD的眼睛进行前瞻性成像。对于每只眼睛，CFP上至少有2 / 3的视网膜专家同意出现结节的区域产生复合CFP结节图。自动图像分析生成了另一张CFP图。在SD OCT b扫描上分割出的病灶区域绘制为SD OCT病灶图。比较CFP和SD OCT图，并对一致性进行量化。分歧被划分为不同的类型，每种类型的频率被量化。CFP和SD OCT在识别结节存在与否方面基本一致，在总像元的82±9%范围内平均一致。大多数不一致（80±15%）发生在瘤缘。SD OCT对大眼珠和色素沉着的眼珠的检出率更高。CFP对小毒株的检出率有较高的趋势。我们证明了CFP和SD oct在毒瘤检测方面的良好一致性。不同的地方强调了基于CFP的毒瘤测量的局限性，特别是在大的、软的毒瘤的尺寸上。SD OCT作为评估AMD患者疲劳负担的辅助工具大有希望。
Spectral domain optical coherence tomography (SD OCT) may be useful for efficient measurement of drusen in patients with age-related macular degeneration (AMD). We evaluated areas identified as drusen from semi-automated segmentation of drusen on SD OCT versus those identified from review of digital color fundus photographs (CFP). Twelve eyes with non-neovascular AMD were prospectively imaged with digital CFP and SD OCT. For each eye, areas on CFP in which at least 2 of 3 retina specialists agreed upon drusen presence produced the composite CFP drusen map. Automated image analysis produced another CFP map. Areas identified as drusen by segmentation on SD OCT B-scans were plotted as the SD OCT drusen map. The CFP and SD OCT maps were compared and agreement was quantified. Disagreement was characterized into distinct types and the frequency of each type was quantified. There was general agreement between CFP and SD OCT in identifying presence and absence of drusen, with mean agreement in 82±9% of total image pixels. Most disagreement (80±15%) occurred at drusen margins. There was a trend for greater detection of drusen with SD OCT in eyes with larger drusen and with hyperpigmentation. There was a trend for greater detection of smaller drusen by CFP. We demonstrate good agreement in drusen detection between CFP and SD OCT. Areas of disagreement underscore limitations of CFP-based measurement of drusen, particularly in the sizing of large, soft drusen. SD OCT shows great promise as an adjunctive tool for assessing drusen burden in AMD.
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影响因子：
13.7
作者：
Schuman SG;Koreishi AF;Farsiu S;Jung SH;Izatt JA;Toth CA
通讯作者：
Toth CA
影响因子：
13.7
作者：
Wojtkowski, M;Srinivasan, V;Duker, JS
通讯作者：
Duker, JS
影响因子：
--
作者：
van Leeuwen, R;Klaver, CCW;de Jong, PTVM
通讯作者：
de Jong, PTVM
影响因子：
10.6
作者：
Xu, CY;Prince, JL
通讯作者：
Prince, JL
影响因子：
4.1
作者：
Pieroni, CG;Witkin, AJ;Duker, JS
通讯作者：
Duker, JS