Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci.
Progression of intermediate age-related macular degeneration with proliferation and inner retinal migration of hyperreflective foci.
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DOI：
10.1016/j.ophtha.2012.10.018
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发表时间：
2013-05
期刊：
影响因子：
13.7
通讯作者：
Age-related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
中科院分区：
文献类型：
--
作者：
Christenbury JG;Folgar FA;O'Connell RV;Chiu SJ;Farsiu S;Toth CA;Age-related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
玻璃疣和迁移性视网膜色素上皮与光谱域光学相干断层扫描（SDOCT）检测到的高反射灶（HF）相关。本研究旨在量化视网膜内HF分布的变化及其与年龄相关性黄斑变性（AMD）疾病进展的相关性。来自多中心眼科相关眼病研究2（AREDS 2）辅助SDOCT研究的前瞻性观察性研究。入组的患者（n = 299）的一只眼睛患有中度AMD和基线SDOCT，随后在1年和2年访视时进行SDOCT成像。对所有299只眼进行SDOCT扫描，对HF的数量和位置进行评分。用成对符号秩和检验评价HF在黄斑中的横向（水平）和轴向（垂直）分布的变化。通过计算每只眼睛的HF加权轴向分布评分（AxD）的变化来确定2年内视网膜HF迁移。用Logistic回归分析评估HF与AMD进展的SDOCT特征的相关性。HF数量、黄斑中HF的横向和轴向分布以及每只眼AxD的平均变化。在299只研究眼中，每只眼HF（p < 0.001）和AxD（p < 0.001）数量的2年增加分别代表纵向增殖和向视网膜内层转移。2年时地图样萎缩（GA）的眼睛与基线HF的存在相关（p < 0.001;比值比[OR]，4.72; 95%置信区间[CI]，2.43-9.80），基线HF数量更多（p < 0.001; OR，1.61/HF; 95% CI，1.32-2.00）和更高的基线AxD（p < 0.001; OR，1.58/AxD点; 95% CI，1.29- 1.95）。中度AMD患者在随访期间发生了SDOCT HF的增殖和视网膜内迁移。这些特征与第2年GA发生率较高相关;因此，SDOCT HF增殖和迁移可作为AMD进展的生物标志物。
Drusen and migrating retinal pigment epithelium have been associated with hyperreflective foci (HF) detected by spectral domain optical coherence tomography (SDOCT). This study sought to quantify the change in intraretinal HF distribution and its correlation with age-related macular degeneration (AMD) disease progression. Prospective observational study from the multicenter Age-Related Eye Disease Study 2 (AREDS2) Ancillary SDOCT Study. Patients (n = 299) with one enrolled eye with intermediate AMD and baseline SDOCT, followed by SDOCT imaging at 1-year and 2-year visits. The number and location of HF were scored in SDOCT scans of all 299 eyes. The change in transverse (horizontal) and axial (vertical) distribution of HF in the macula were evaluated with pairwise signed rank tests. Two-year inner retinal HF migration was determined by the change in HF weighted axial distribution score (AxD) calculated for each eye. The correlation of HF with SDOCT features of AMD progression was evaluated with logistic regression analysis. Mean change in number of HF, transverse and axial distribution of HF in the macula, and the AxD per eye. In 299 study eyes, the 2-year increase in the number of HF (p < 0.001) and AxD (p < 0.001) per eye represented longitudinal proliferation and shift to inner retinal layers, respectively. Eyes with geographic atrophy (GA) at 2 years were correlated with presence of baseline HF (p < 0.001; odds ratio [OR], 4.72; 95% confidence interval [CI], 2.43–9.80), greater number of baseline HF (p < 0.001; OR, 1.61 per HF; 95% CI, 1.32–2.00) and greater baseline AxD (p < 0.001; OR, 1.58 per AxD point; 95% CI, 1.29– 1.95). Proliferation and inner retinal migration of SDOCT HF occurred during follow-up in eyes with intermediate AMD. These characteristics were associated with greater incidence of GA at year 2; therefore, SDOCT HF proliferation and migration may serve as biomarkers for AMD progression.
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影响因子：
4
作者：
Venza, Isabella;Visalli, Maria;Venza, Mario
通讯作者：
Venza, Mario
影响因子：
13.7
作者：
Schuman SG;Koreishi AF;Farsiu S;Jung SH;Izatt JA;Toth CA
通讯作者：
Toth CA
影响因子：
13.7
作者：
Hee, MR;Baumal, CR;Fujimoto, JG
通讯作者：
Fujimoto, JG
DOI：
10.1111/j.1395-3907.2003.00170.x
发表时间：
2003-12-01
期刊：
ACTA OPHTHALMOLOGICA SCANDINAVICA
影响因子：
--
作者：
Mitsuhiro, MRKH;Eguchi, S;Yamashita, H
通讯作者：
Yamashita, H
影响因子：
13.7
作者：
Klein, Ronald;Klein, Barbara E. K.;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.