Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro‐histology

Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro‐histology
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使用磁共振显微组织学增强发育中小鼠大脑的组织分化

DOI:
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发表时间:
2013
影响因子:
3.3
通讯作者:
M. Lythgoe
M. Lythgoe
中科院分区:
医学3区
文献类型:
--
作者:
F. Norris;J. Betts;J. Wells;J. Cleary;B. Siow;S. Walker;K. McCue;P. Salomoni;P. Scambler;M. Lythgoe

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目的:全球了解发育过程的努力需要新的高分辨率3D成像方法来检测胚胎发育和疾病中基因功能的后果。令人鼓舞的是,最近的研究表明,MRI造影剂可以突出显示离体成年小鼠大脑中的特定组织结构。小鼠胚胎的MR成像目前受到缺乏组织染色能力的限制,组织染色能力将提供常规用于小鼠胚胎表型分析的组织学染色剂所提供的灵活性和特异性。
Purpose: Worldwide efforts to understand developmental processes demand new high‐resolution 3D imaging methods to detect the consequences of gene function in embryo development and diseases. Encouragingly, recent studies have shown that MRI contrast agents can highlight specific tissue structures in ex vivo adult mouse brains. MR imaging of mouse embryos is currently limited by a lack of tissue staining capabilities that would provide the flexibility and specificity offered by histological stains conventionally used for mouse embryo phenotyping.
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