Nomogram for predicting preoperative lymph node involvement in patients with invasive micropapillary carcinoma of breast: a SEER population-based study.
Nomogram for predicting preoperative lymph node involvement in patients with invasive micropapillary carcinoma of breast: a SEER population-based study.
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预测乳腺浸润性微乳头状癌患者术前淋巴结受累的列线图：一项基于 SEER 人群的研究
DOI：
10.1186/s12885-018-4982-5
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发表时间：
2018-11-08
期刊：
影响因子：
3.8
通讯作者：
Shao ZM
中科院分区：
文献类型：
--
作者：
Ye FG;Xia C;Ma D;Lin PY;Hu X;Shao ZM
背景浸润性微乳头状癌（IMPC）是一种少见的乳腺浸润性肿瘤，具有高度的区域淋巴结转移倾向。本研究旨在确定乳腺IMPC的危险因素，并制定一个诺模图术前预测淋巴结involvement.MethodsA回顾性审查的可能性IMPC的患者诊断与监测，流行病学和最终结果（SEER）数据库在2003年和2014年之间的临床和病理记录。将队列分为训练集和验证集。训练集包括2003年至2009年期间诊断的患者，而验证集包括此后诊断的患者。使用逻辑回归模型在训练集中构建诺模图，然后在验证集中进行验证。诺模图的性能进行量化方面的歧视和校准使用R 3.4.1 software.ResultsOverall，1407例确诊为IMPC患者入组，其中527训练集和880验证集。逻辑回归分析表明，较大的病变、诊断时年龄较小、黑人种族和缺乏激素受体表达与区域淋巴结受累显着相关。诺模图的AUC为0.735（95%置信区间（CI）为0.692至0.777），显示出良好的预测性能。绘制了诺模图的校准曲线，斜率接近1，这表明诺模图具有良好的校准。诺模图的性能进一步验证的验证集，AUC为0.748（95%CI 0.701至0.767）。ConclusionsThe IMPC和IDC之间的显着差异仍然是IMPC淋巴结受累增加，因此值得积极治疗。建立了基于临床病理参数的诺模图，可准确预测术前区域淋巴结状态。此列线图将有助于术前评估淋巴结状态，从而为个体患者的治疗决策提供帮助。
BackgroundInvasive micropapillary carcinoma (IMPC) is an unusual and distinct subtype of invasive breast tumor with high propensity for regional lymph node metastases. This study was to identify risk factors accounting for IMPC of the breast and to develop a nomogram to preoperatively predict the probability of lymph node involvement.MethodsA retrospective review of the clinical and pathology records was performed in patients diagnosed with IMPC between 2003 and 2014 from Surveillance, Epidemiology, and End Results (SEER) database. The cohort was divided into training and validation sets. Training set comprised patients diagnosed between 2003 and 2009, while validation set included patients diagnosed thereafter. A logistic regression model was used to construct the nomogram in the training set and then varified in the validation set. Nomogram performance was quantified with respect to discrimination and calibration using R 3.4.1 software.ResultsOverall, 1407 patients diagnosed with IMPC were enrolled, of which 527 in training set and 880 in validation set. Logistic regression analysis indicated larger lesions, younger age at diagnosis, black ethnic and lack of hormone receptor expression were significantly related to regional nodes involvement. The AUC of the nomogram was 0.735 (95% confidential interval (CI) 0.692 to 0.777), demonstrating a good prediction performance. Calibration curve for the nomogram was plotted and the slope was close to 1, which demonstrated excellent calibration of the nomogram. The performance of the nomogram was further validated in the validation set, with AUC of 0.748 (95% CI 0.701 to 0.767).ConclusionsThe striking difference between IMPC and IDC remains the increased lymph node involvement in IMPC and therefore merits aggressive treatment. The nomogram based on the clinicalpathologic parameters was established, which could accurately preoperatively predict regional lymph node status. This nomogram would facilitate evaluating lymph node state preoperatively and thus treatment decision-making of individual patients.
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影响因子：
3.5
作者：
Pettinato, G;Manivel, CJ;Petrella, G
通讯作者：
Petrella, G
DOI：
10.2325/jbcs.13.58
发表时间：
2006-01-01
期刊：
Breast cancer (Tokyo, Japan)
影响因子：
--
作者：
Li, Yu-sang;Kaneko, Mayumi;Inai, Kouki
通讯作者：
Inai, Kouki
影响因子：
1.2
作者：
Chen, Ling;Fan, Yu;Fu, Li
通讯作者：
Fu, Li
SDF-1/CXCR4 表达增加与乳腺浸润性微乳头状癌淋巴结转移相关
影响因子：
6.4
作者：
Liu, Fangfang;Lang, Ronggang;Fu, Li
通讯作者：
Fu, Li
影响因子：
1.9
作者：
RASPONI, A;COSTA, A;CASCINELLI, N
通讯作者：
CASCINELLI, N