An Updated Review of Hypertrophic Scarring.

An Updated Review of Hypertrophic Scarring.
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DOI:
10.3390/cells12050678
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发表时间:
2023-02-21
期刊:
影响因子:
6
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
作者:

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增生性瘢痕形成(HTS)是一种异常形式的伤口愈合,这是与过度沉积的细胞外基质和结缔组织在损伤部位。在这篇综述文章中,我们提供了正常(急性)伤口愈合阶段(止血,炎症,增殖和重塑)的概述。我们接下来讨论与HTS发展相关的伤口愈合阶段的失调和/或受损机制。接下来我们讨论HTS的动物模型及其局限性,并回顾HTS的当前和新兴治疗方法。
Hypertrophic scarring (HTS) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. In this review article, we provide an overview of normal (acute) wound healing phases (hemostasis, inflammation, proliferation, and remodeling). We next discuss the dysregulated and/or impaired mechanisms in wound healing phases that are associated with HTS development. We next discuss the animal models of HTS and their limitations, and review the current and emerging treatments of HTS.
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