An Update on the Role of Serotonin and its Interplay with Dopamine for Reward.
An Update on the Role of Serotonin and its Interplay with Dopamine for Reward.
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DOI：
10.3389/fnhum.2017.00484
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发表时间：
2017
影响因子：
2.9
通讯作者：
Ullsperger M
中科院分区：
文献类型：
--
作者：
Fischer AG;Ullsperger M
血清素的具体作用及其与多巴胺 (DA) 在适应性、奖励引导行为以及药物依赖性中的相互作用仍然难以捉摸。最近，新方法允许对血清素能和多巴胺能回路进行细胞类型特异性解剖、功能和介入分析，有望在理解其功能作用方面取得重大进展。此外，人们越来越认识到神经递质的共同释放在功能上是相关的，为了解释药理学研究的结果及其与神经记录的关系，需要了解这一点。在这里，我们回顾了最近采用此类技术的动物研究，旨在将其结果与人类药理学研究中观察到的效果和药物的主观效果联系起来。看来，血清素和 DA 的相加效应传达了重要的奖励相关信息，并且在主观上是高度欣快的。单独使用 DA 或血清素都没有这样的效果。这与小鼠的光遗传学目标记录相吻合，其中多巴胺能系统编码奖励预测错误（PE），而血清素能系统主要编码未签名的PE。总体而言，这种结果模式表明两个系统之间的联合活动携带着重要的奖励信息，并需要对两个神经递质系统进行并行研究。
The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward guided behavior as well as drug dependance, still remains elusive. Recently, novel methods allowed cell type specific anatomical, functional and interventional analyses of serotonergic and dopaminergic circuits, promising significant advancement in understanding their functional roles. Furthermore, it is increasingly recognized that co-release of neurotransmitters is functionally relevant, understanding of which is required in order to interpret results of pharmacological studies and their relationship to neural recordings. Here, we review recent animal studies employing such techniques with the aim to connect their results to effects observed in human pharmacological studies and subjective effects of drugs. It appears that the additive effect of serotonin and DA conveys significant reward related information and is subjectively highly euphorizing. Neither DA nor serotonin alone have such an effect. This coincides with optogenetically targeted recordings in mice, where the dopaminergic system codes reward prediction errors (PE), and the serotonergic system mainly unsigned PE. Overall, this pattern of results indicates that joint activity between both systems carries essential reward information and invites parallel investigation of both neurotransmitter systems.
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
3.3
作者：
BAKER, KG;HALLIDAY, GM;TORK, I
通讯作者：
TORK, I
影响因子：
7.3
作者：
Bauer, C. T.;Banks, M. L.;Negus, S. S.
通讯作者：
Negus, S. S.
影响因子：
3.7
作者：
Branchi, Igor
通讯作者：
Branchi, Igor
DOI：
10.1523/jneurosci.2513-09.2009
发表时间：
2009-09-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Crockett MJ;Clark L;Robbins TW
通讯作者：
Robbins TW