Structure-Based Analysis of Single Nucleotide Variants in the Renin-Angiotensinogen Complex.
Structure-Based Analysis of Single Nucleotide Variants in the Renin-Angiotensinogen Complex.
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DOI：
10.1016/j.gheart.2017.01.006
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发表时间：
2017-06
期刊：
影响因子：
3.7
通讯作者：
Tastan Bishop Ö
中科院分区：
文献类型：
--
作者：
Brown DK;Sheik Amamuddy O;Tastan Bishop Ö
肾素-血管紧张素系统(RAS)在调节血压和控制血液中的钠水平方面起着重要作用。这一系统的过度活动与许多疾病有关，包括高血压、肾脏疾病和充血性心力衰竭。因此，已经开发了各种类型的药物来抑制这一系统。这些药物旨在通过抑制血管紧张素II受体或抑制血管紧张素转换酶将血管紧张素I转化为血管紧张素II来阻止血管紧张素II发挥其功能。最后一类抑制剂旨在通过阻止肾素与一种名为血管紧张素原的血浆蛋白相互作用来防止血管紧张素I的形成。在这项研究中，我们对单核苷酸变异对肾素和血管紧张素原相互作用的影响进行了结构分析，目的是揭示重要的残基和潜在的破坏性变异。
The Renin-Angiotensin System (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. As such, various classes of drugs have been developed to inhibit this system. These drugs are aimed at preventing angiotensin II from performing its function by inhibiting angiotensin II receptors or inhibiting angiotensin-converting enzyme from converting angiotensin I to angiotensin II. The last class of inhibitors is aimed at preventing angiotensin I from being formed by preventing renin from interacting with a plasma protein called angiotensinogen. In this study, we provide a structure-based analysis of the effect of single nucleotide variants on the interaction between renin and angiotensinogen with the aim of revealing important residues and potentially damaging variants.
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