Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction.
Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction.
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DOI：
10.1016/j.psyneuen.2013.09.022
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发表时间：
2014-01
影响因子：
3.7
通讯作者：
Pagnoni, Giuseppe
中科院分区：
文献类型：
--
作者：
Rilling, James K.;DeMarco, Ashley C.;Hackett, Patrick D.;Chen, Xu;Gautam, Pritam;Stair, Sabrina;Haroon, Ebrahim;Thompson, Richmond;Ditzen, Beate;Patel, Rajan;Pagnoni, Giuseppe
催产素（OT）和加压素（AVP）都是已知的调节社会行为，这两个系统的功能障碍已被假定为涉及社会行为缺陷的某些精神疾病的潜在原因。特别是，人们越来越关注鼻内OT作为某些精神疾病的潜在治疗方法，初步的临床前和临床研究表明其在缓解一些相关症状方面的疗效。然而，这些研究中的绝大多数研究参与者都是男性，并且有证据表明九肽在人类和非人类动物中具有性别差异效应。迄今为止，没有研究调查鼻内OT对相同范例中的人类男性和女性的脑功能的影响。以前，在一项随机，安慰剂对照，双盲fMRI研究中，我们报告了鼻内OT和AVP对人类男性行为和大脑活动的影响，因为他们玩了一个互动的社交游戏，称为囚徒困境游戏。在这里，我们提出了来自人类女性的相同研究的结果，并将其与我们在男性中的发现进行比较。总之，我们发现，行为和神经反应鼻内OT和AVP是高度性别分化。在女性中，AVP增加了和解行为，OT和AVP都使女性更像对待人类一样对待电脑伴侣。在男性中，AVP增加了人类和计算机合作伙伴的合作回报。然而，男性和女性之间没有特定的药物对行为的影响。在合作互动过程中，OT和AVP都增加了男性大脑中富含OT和AVP受体的区域以及在奖励、社会联系、唤醒和记忆中起关键作用的区域（例如，纹状体、基底前脑、海马、杏仁核和海马），而OT和AVP要么没有影响，要么在某些情况下实际上降低了女性这些区域的大脑活动。OT治疗使男性的神经反应更类似于安慰剂组中女性的反应，反之亦然，提高了中央OT水平的倒U形剂量反应的前景。这些研究结果强调，需要充分表征鼻内OT和AVP在男性和女性中的作用，以及在广泛的临床应用之前，需要进行多次给药。
Both oxytocin (OT) and vasopressin (AVP) are known to modulate social behavior, and dysfunction in both systems has been postulated as a potential cause of certain psychiatric disorders that involve social behavioral deficits. In particular, there is growing interest in intranasal OT as a potential treatment for certain psychiatric disorders, and preliminary preclinical and clinical studies suggest efficacy in alleviating some of the associated symptoms. However, the vast majority of research participants in these studies have been male, and there is evidence for sexually differentiated effects of nonapeptides in both humans and non-human animals. To date, no study has investigated the effect of intranasal OT on brain function in human males and females within the same paradigm. Previously, in a randomized, placebocontrolled, double-blind fMRI study, we reported effects of intranasal OT and AVP on behavior and brain activity of human males as they played an interactive social game known as the Prisoner’s Dilemma Game. Here, we present findings from an identical study in human females, and compare these with our findings from males. Overall, we find that both behavioral and neural responses to intranasal OT and AVP are highly sexually differentiated. In women, AVP increased conciliatory behavior, and both OT and AVP caused women to treat computer partners more like humans. In men, AVP increased reciprocation of cooperation from both human and computer partners. However, no specific drug effects on behavior were shared between men and women. During cooperative interactions, both OT and AVP increased brain activity in men within areas rich in OT and AVP receptors and in areas playing a key role in reward, social bonding, arousal and memory (e.g., the striatum, basal forebrain, insula, amygdala and hippocampus), whereas OT and AVP either had no effect or in some cases actually decreased brain activity in these regions in women. OT treatment rendered neural responses of males more similar to responses of females in the placebo group and vice-versa, raising the prospect of an inverted u-shaped dose response to central OT levels. These findings emphasize the need to fully characterize the effects of intranasal OT and AVP in both males and females and at multiple doses before widespread clinical application will be warranted.
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影响因子：
6.2
作者：
Anagnostou E;Soorya L;Chaplin W;Bartz J;Halpern D;Wasserman S;Wang AT;Pepa L;Tanel N;Kushki A;Hollander E
通讯作者：
Hollander E
影响因子：
11
作者：
Kim, SJ;Young, LJ;Insel, TR
通讯作者：
Insel, TR
影响因子：
16.2
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
影响因子：
11.4
作者：
AUDIGIER, S;BARBERIS, C
通讯作者：
BARBERIS, C
影响因子：
10.6
作者：
Guastella, Adam J.;Einfeld, Stewart L.;Hickie, Ian B.
通讯作者：
Hickie, Ian B.