The polymorphism in the let-7 targeted region of the Lin28 gene is associated with increased risk of type 2 diabetes mellitus
The polymorphism in the let-7 targeted region of the Lin28 gene is associated with increased risk of type 2 diabetes mellitus
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Lin28 基因 let-7 目标区域的多态性与 2 型糖尿病风险增加相关
DOI：
10.1016/j.mce.2013.04.022
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发表时间：
2013-08
影响因子：
4.1
通讯作者：
Jianxin Lu
中科院分区：
文献类型：
--
作者：
Jie Zhang;Longyi Zhang;Runping Fan;Nengneng Guo;Chunhui Xiong;Lin Wang;Sheng Jin;Wei Li;Jianxin Lu
疾病发病机制中miRNAs途径的遗传多态可能与疾病的风险有关。然而，目前尚不清楚miRNAs的这些多态性是否与2型糖尿病(T2 DM)的风险有关。我们对588名T2 DM患者和588名年龄和性别匹配的对照组进行了一项病例对照研究，以研究let-7/Lin28通路的两个多态性。结果显示，rs3811463基因多态性与T2 DM的危险性增加相关(OR=1.47，95%可信区间(95%CI)=1.13~1.93，P=0.005)，而rs3811464基因多态性与T2 DM的发病风险无关(OR=1.04，95%CI=0.79~1.36，P=0.78)。Rs3811463基因变异与女性发病风险相关；在T2 DM患者中，rs3811463基因变异与野生型在发病年龄、高血压、周围神经病变等临床特征上存在统计学差异。综上所述，LET-7/LIN28通路中rs3811463基因多态性可显著增加T2 DM的发病风险。
Genetic polymorphisms in the miRNAs pathway of the pathogenesis of disease might contribute to the risk of disease. However, it is unclear whether these polymorphisms about miRNAs are associated with the risk of type 2 diabetes mellitus (T2DM). We performed a case-control study to investigate two polymorphisms in the let-7/Lin28 pathway based on 588 T2DM patients and 588 age and sex matched controls. The results showed that the rs3811463 polymorphism was associated with increased risk of T2DM (odds ratio (OR)=1.47, 95% confidence inference (95%CI)=1.13–1.93, P=0.005), while the rs3811464 not (OR=1.04, 95%CI=0.79–1.36, P=0.78). For the rs3811463 polymorphism, the variant genotypes were associated with increased risk of disease in females; statistically differences were observed in the clinical features of age at diagnosis, hypertension and peripheral neuropathy for the variant and wild genotype of the rs3811463 in T2DM. In summary, the results indicated that the rs3811463 polymorphism in the let-7/Lin28 pathway could significantly increase the risk of T2DM.
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影响因子：
3.7
作者：
Patel CJ;Bhattacharya J;Butte AJ
通讯作者：
Butte AJ
影响因子：
3.4
作者：
A. Rauseo;A. Pacilli;A. Palena;S. De Cosmo
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A. Rauseo;A. Pacilli;A. Palena;S. De Cosmo
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影响因子：
3.7
作者：
Greco D;Kivi N;Qian K;Leivonen SK;Auvinen P;Auvinen E
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Auvinen E
影响因子：
168.9
作者：
Tahrani, Abd A.;Bailey, Clifford J.;Barnett, Anthony H.
通讯作者：
Barnett, Anthony H.
影响因子：
4.1
作者：
V. Toušková;P. Trachta;P. Kavalkova;J. Drápalová;D. Haluzíková;M. Mráz;Z. Lacinová;J. Marek;M. Haluzík
通讯作者：
V. Toušková;P. Trachta;P. Kavalkova;J. Drápalová;D. Haluzíková;M. Mráz;Z. Lacinová;J. Marek;M. Haluzík