Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.
Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.
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DOI：
10.1016/j.conb.2011.04.010
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发表时间：
2011-12
影响因子：
5.7
通讯作者：
Feng G
中科院分区：
文献类型：
--
作者：
Ting JT;Feng G
强迫症（OCD）的确切原因尚不清楚，然而，数十年的研究已经将大脑中的皮质-纹状体-丘脑-皮质（CSTC）回路作为参与强迫症和密切相关的强迫重复行为的关键途径。人类和小鼠遗传学的最新进展导致了新的候选易感基因的鉴定，这反过来又促进了一种更有针对性的方法来揭示强迫症中电路功能障碍的本质。在强迫症的遗传动物模型中进行侵入性技术的能力对于该领域的快速发展至关重要，因此，我们回顾了最近的发展，并强调了寻找强迫重复行为背后的常见电路缺陷的重要性。
The precise causal factors for obsessive-compulsive disorder (OCD) are not known, however, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive-repetitive behaviors.
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