Immune cells in lens injury repair and fibrosis.
Immune cells in lens injury repair and fibrosis.
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DOI：
10.1016/j.exer.2021.108664
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发表时间：
2021-08
影响因子：
3.4
通讯作者：
Menko AS
中科院分区：
文献类型：
--
作者：
Walker JL;Menko AS
免疫细胞，包括组织驻留免疫细胞和响应于创伤或退行性病症而募集的那些免疫细胞，对于大多数组织中的稳态的维持和恢复都是必不可少的。这些细胞通常通过其紧密相关的血管系统提供给组织。然而，透镜与眼睛中的许多组织一样，被认为是免疫特权部位，因为它们没有相关的脉管系统。这种免疫细胞的缺乏被认为是保护透镜免受炎症反应的影响，炎症反应会带来导致视力损害混浊的危险。然而，现在已经表明，正如在眼睛中的其他免疫特权部位所发生的那样，存在新的途径，免疫细胞通过该途径与透镜相关联以保护它，维持其稳态，并在其再生修复中发挥作用。在这里，我们回顾的发现，揭示了先天性和适应性免疫系统的反应，透镜，和大多数其他组织一样，透镜窝藏一个居民免疫细胞，这是危险或损伤的组织的哨兵。虽然驻留和募集的免疫细胞是透镜稳态和修复的基本要素，但它们也成为疾病的因子，特别是作为促纤维化肌成纤维细胞的祖细胞。关于晶状体相关免疫细胞在保护、修复和疾病中的功能，仍有许多需要了解的，这些知识将为维持视觉系统中透镜的核心功能提供新的工具。
Immune cells, both tissue resident immune cells and those immune cells recruited in response to wounding or degenerative conditions, are essential to both the maintenance and restoration of homeostasis in most tissues. These cells are typically provided to tissues by their closely associated vasculatures. However, the lens, like many of the tissues in the eye, are considered immune privileged sites because they have no associated vasculature. Such absence of immune cells was thought to protect the lens from inflammatory responses that would bring with them the danger of causing vision impairing opacities. However, it has now been shown, as occurs in other immune privileged sites in the eye, that novel pathways exist by which immune cells come to associate with the lens to protect it, maintain its homeostasis, and function in its regenerative repair. Here we review the discoveries that have revealed there are both innate and adaptive immune system responses to lens, and that, like most other tissues, the lens harbors a population of resident immune cells, which are the sentinels of danger or injury to a tissue. While resident and recruited immune cells are essential elements of lens homeostasis and repair, they also become the agents of disease, particularly as progenitors of pro-fibrogenic myofibroblasts. There still remains much to learn about the function of lens-associated immune cells in protection, repair and disease, the knowledge of which will provide new tools for maintaining the core functions of the lens in the visual system.
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影响因子：
2.8
作者：
Dohlman, Claes H.;Zhou, Chengxin;Paschalis, Eleftherios, I
通讯作者：
Paschalis, Eleftherios, I
影响因子：
3.6
作者：
CUADROS, MA;MARTIN, C;NAVASCUES, J
通讯作者：
NAVASCUES, J
影响因子：
4.9
作者：
Dejaco, Christian;Klotz, Werner;Herold, Manfred
通讯作者：
Herold, Manfred
影响因子：
4.8
作者：
DeDreu, JodiRae;Bowen, Caitlin J.;Menko, A. Sue
通讯作者：
Menko, A. Sue
影响因子：
29
作者：
Bharath, Leena P.;Agrawal, Madhur;Nikolajczyk, Barbara S.
通讯作者：
Nikolajczyk, Barbara S.