Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach.
Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach.
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DOI：
10.1038/s41598-023-29596-8
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发表时间：
2023-02-10
影响因子：
4.6
通讯作者：
Iwasaki, Motoki
中科院分区：
文献类型：
--
作者：
Katagiri, Ryoko;Goto, Atsushi;Nakano, Shiori;Nakatochi, Masahiro;Koyanagi, Yuriko N.;Iwagami, Masao;Hanyuda, Akiko;Yamaji, Taiki;Sawada, Norie;Nakamura, Yohko;Nakamura, Sho;Kuriki, Kiyonori;Suzuki, Sadao;Imoto, Issei;Momozawa, Yukihide;Oze, Isao;Ito, Hidemi;Tsugane, Shoichiro;Wakai, Kenji;Matsuo, Keitaro;Iwasaki, Motoki
在观察性研究中，维生素D与总风险和结直肠癌风险之间的关系并不一致。我们采用孟德尔随机化方法，可以减少混杂的影响。根据“GWAS目录”系统地从所有民族人群中筛选出110个与25-羟基维生素D浓度相关的单核苷酸多态性（snp）。对于snp -维生素D浓度关联，包括来自两个日本队列的3978个人。在SNP-total与结直肠癌的相关性方面，分别从日本遗传流行病学联合会和日本其他研究中纳入了4543例癌症病例和14224例对照，7936例结直肠癌病例和38042例对照。在任何MR分析中，基因预测的血浆25-羟基维生素D浓度与总或结直肠癌之间没有显著关联。在反方差加权法中，总癌症的维生素D浓度每增加一倍的优势比为0.83(95%可信区间[CI] 0.63-1.09)，结直肠癌的优势比为1.00 (95% CI 0.80-1.24)， MR-Egger法中，总癌症的优势比为0.83 (95% CI 0.57-1.19)，结直肠癌的优势比为1.01 （95% CI 0.75-1.37）。与之前对欧洲祖先的MR分析一致，25-羟基维生素D水平与亚洲人的总癌症或结直肠癌之间没有明显的关联。
The association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentrations were systematically selected according to the “GWAS Catalog” from all ethnic populations. For the SNP-vitamin D concentration association, 3978 individuals from two Japanese cohorts were included. Regarding SNP-total and colorectal cancer association, 4543 cancer cases and 14,224 controls and 7936 colorectal cancer cases and 38,042 controls, respectively were included from the Japanese Consortium of Genetic Epidemiology and other studies in Japan. There was no significant association between the genetically predicted plasma 25-hydroxyvitamin D concentration and total or colorectal cancer in any of the MR analyses. Odds ratios per doubling in vitamin D concentration were 0.83 (95% confidence interval [CI] 0.63–1.09) for total cancer and 1.00 (95% CI 0.80–1.24) for colorectal cancer in inverse variance weighted method, 0.83 (95% CI 0.57–1.19) for total cancer and 1.01 (95% CI 0.75–1.37) for colorectal cancer in MR-Egger method. Consistent with previous MR analyses among European ancestries, there was no significant association identified between 25-hydroxyvitamin D levels and total or colorectal cancer among Asians.
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DOI：
10.1136/bmj.k601
发表时间：
2018-07-12
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Davies NM;Holmes MV;Davey Smith G
通讯作者：
Davey Smith G
影响因子：
6.4
作者：
He, Yazhou;Zhang, Xiaomeng;Dunlop, Malcolm G.
通讯作者：
Dunlop, Malcolm G.
影响因子：
28.4
作者：
Scragg, Robert;Khaw, Kay-Tee;Camargo, Carlos A., Jr.
通讯作者：
Camargo, Carlos A., Jr.
DOI：
10.3945/ajcn.115.118216
发表时间：
2016-04
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Haycock PC;Burgess S;Wade KH;Bowden J;Relton C;Davey Smith G
通讯作者：
Davey Smith G
影响因子：
16.6
作者：
Ong JS;Dixon-Suen SC;Han X;An J;Esophageal Cancer Consortium;23 and Me Research Team;Liyanage U;Dusingize JC;Schumacher J;Gockel I;Böhmer A;Jankowski J;Palles C;O'Mara T;Spurdle A;Law MH;Iles MM;Pharoah P;Berchuck A;Zheng W;Thrift AP;Olsen C;Neale RE;Gharahkhani P;Webb PM;MacGregor S
通讯作者：
MacGregor S