Multidrug-Resistant Corynebacterium striatum Associated with Increased Use of Parenteral Antimicrobial Drugs.
Multidrug-Resistant Corynebacterium striatum Associated with Increased Use of Parenteral Antimicrobial Drugs.
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DOI：
10.3201/eid2211.160141
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发表时间：
2016-11
影响因子：
11.8
通讯作者：
Rakita RM
中科院分区：
文献类型：
--
作者：
Hahn WO;Werth BJ;Butler-Wu SM;Rakita RM
与该病原体相关的器械感染通常需要长期的胃肠外治疗。纹状体棒状杆菌是一种新兴的多重耐药菌。我们在临床数据库中回顾性地鉴定了179株分离株。临床相关性、体外敏感性和肠外抗菌药物使用时间均来自患者记录。对于硬件或器械相关感染的患者，C.纹状体感染与凝固酶阴性葡萄球菌感染患者进行配对，进行病例对照分析。共有87（71%）121株耐药的所有口服抗菌药物测试，包括青霉素，四环素，克林霉素，红霉素，环丙沙星。当与硬件或设备隔离时，C.纹状体病变38例（87%）。与硬件相关的C.纹状体感染患者接受肠外抗菌药物治疗的时间长于硬件相关凝固酶阴性葡萄球菌感染患者（平均值± SD 69 ± 5天vs. 25 ± 4天; p<0.001）。C.纹状体通常显示出对具有口服生物利用度的抗微生物药物的抗性，并且与胃肠外抗微生物药物的使用增加有关。
Device-related infections with this pathogen frequently require prolonged parenteral therapy. Corynebacterium striatum is an emerging multidrug-resistant bacteria. We retrospectively identified 179 isolates in a clinical database. Clinical relevance, in vitro susceptibility, and length of parenteral antimicrobial drug use were obtained from patient records. For patients with hardware- or device-associated infections, those with C. striatum infections were matched with patients infected with coagulase-negative staphylococci for case–control analysis. A total of 87 (71%) of 121 isolates were resistant to all oral antimicrobial drugs tested, including penicillin, tetracycline, clindamycin, erythromycin, and ciprofloxacin. When isolated from hardware or devices, C. striatum was pathogenic in 38 (87%) of 44 cases. Patients with hardware-associated C. striatum infections received parenteral antimicrobial drugs longer than patients with hardware-associated coagulase-negative staphylococci infections (mean ± SD 69 ± 5 days vs. 25 ± 4 days; p<0.001). C. striatum commonly shows resistance to antimicrobial drugs with oral bioavailability and is associated with increased use of parenteral antimicrobial drugs.
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DOI：
10.1007/s10096-014-2188-6
发表时间：
2014-12
影响因子：
4.5
作者：
TeKippe, E. McElvania;Thomas, B. S.;Ewald, G. A.;Lawrence, S. J.;Burnham, C. -A. D.
通讯作者：
Burnham, C. -A. D.
影响因子：
24.3
作者：
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影响因子：
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作者：
GAVIN, SE;LEONARD, RB;COYLE, MB
通讯作者：
COYLE, MB
DOI：
10.1016/j.jinf.2005.08.027
发表时间：
2006-05-01
期刊：
The Journal of infection
影响因子：
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作者：
Mashavi, Margarita;Soifer, Elena;Beigel, Yitzhak
通讯作者：
Beigel, Yitzhak
DOI：
10.1111/j.1469-0691.1997.tb00470.x
发表时间：
1997-02-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Martinez-Martinez, L.;Suarez, A.I.;Muniain, M. A.
通讯作者：
Muniain, M. A.