Repeated inductive heating using a sintered MgFe2O4 needle for minimally invasive local control in breast cancer therapy
Repeated inductive heating using a sintered MgFe2O4 needle for minimally invasive local control in breast cancer therapy
复制标题
使用烧结 MgFe2O4 针重复感应加热，用于乳腺癌治疗中的微创局部控制
DOI：
10.1080/02656730902991459
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发表时间：
2009
影响因子：
3.1
通讯作者：
K. Kawachi
中科院分区：
文献类型：
--
作者：
S. Yukumi;Yuji Watanabe;Atsushi Horiuchi;T. Doi;Kohichi Sato;Motohira Yoshida;Y. Yamamoto;T. Maehara;H. Aono;T. Naohara;K. Kawachi
目的：研究利用新型烧结MgFe2O4针和交流磁场在模拟人类乳腺癌的异种移植动物模型上反复热疗乳腺癌的效果。材料和方法：制备了一种烧结的MgFe2O4针和一种交流磁场施加装置。携带BT-474肿瘤（平均（±标准差）体积为471±153 mm3）的动物分为四组。在每个肿瘤的中心放置一根烧结的MgFe2O4针（长度为5mm）。第一组、第二组和第三组分别施加1次、2次或3次交流磁场（振幅为4 kA/m； 2 kW; 540 kHz），持续10 min，对照组不施加。评估治疗期间的温度和首次治疗后8周的肿瘤体积。结果：重复用药组最高肿瘤温度有升高趋势：1组59.2±4℃；第2组，第一次使用58.9±3.3°C，第二次使用61.2±8.9°C；第3组分别为60.4±4.6°C、62.1±7.8°C和71.1±6.1°C。治疗后8周，对照组、1、2、3组肿瘤体积分别为3633±2478 mm3、3240±1031 mm3、1252±1289 mm3、0 mm3。8周时，第3组的肿瘤明显小于对照组和第1组。结论：利用烧结的MgFe2O4针反复感应加热的效果得到了证实。使用本方法的热疗法可以为人类乳腺癌提供有效的非手术治疗。
Purpose: This study investigated the efficacy of repeated thermotherapy for breast cancer utilising a novel sintered MgFe2O4 needle and alternating current (AC) magnetic field in xenograft animal models mimicking human breast cancer. Materials and methods: A sintered MgFe2O4 needle and an apparatus to apply an AC magnetic field were prepared for this study. Animals bearing BT-474 tumours (mean (±standard deviation) volume, 471 ± 153 mm3) were divided into four groups. A sintered MgFe2O4 needle (length, 5 mm) was placed in the centre of each tumour. An AC magnetic field (amplitude, 4 kA/m; 2 kW; 540 kHz) was applied for 10 min once, twice or three times for the first, second and third groups, respectively, and was not applied for the control group. Temperature during treatment and tumour volume 8 weeks after first treatment were assessed. Results: Maximum tumour temperature tended to increase in repeated-application groups: group 1, 59.2 ± 4°C; group 2, 58.9 ± 3.3°C and 61.2 ± 8.9°C for the first and second applications; and group 3, 60.4 ± 4.6°C, 62.1 ± 7.8°C and 71.1 ± 6.1°C for the first, second and third applications. Tumour volumes in control, groups 1, 2 and 3 at 8 weeks after treatment were 3633 ± 2478 mm3, 3240 ± 1031 mm3, 1252 ± 1289 mm3 and 0 mm3, respectively. Tumours were significantly smaller in group 3 than in the control and group 1 at 8 weeks. Conclusions: The efficacy of repeated inductive heating utilising a sintered MgFe2O4 needle was demonstrated. Thermotherapy using the present method may offer an effective non-surgical treatment for human breast cancer.
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影响因子：
2.8
作者：
Kawai, N;Ito, A;Kohri, K
通讯作者：
Kohri, K
影响因子：
3.9
作者：
T. Ohno;T. Wakabayashi;A. Takemura;J. Yoshida;A. Ito;M. Shinkai;H. Honda;Takeshi Kobayashi
通讯作者：
T. Ohno;T. Wakabayashi;A. Takemura;J. Yoshida;A. Ito;M. Shinkai;H. Honda;Takeshi Kobayashi
影响因子：
5.7
作者：
Hamaguchi, S;Tohnai, I;Ueda, M
通讯作者：
Ueda, M
右旋糖酐磁铁矿复合物新型局部热疗对仓鼠舌癌的抗肿瘤作用
DOI：
--
发表时间：
2003
期刊：
Oral Disease 9
影响因子：
--
作者：
S.Wada;K.Tazawa;I.Furuta;H.Nagae
通讯作者：
H.Nagae