Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study.
Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study.
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DOI：
10.1289/ehp.1002805
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发表时间：
2012-01
影响因子：
10.4
通讯作者：
Schwartz J
中科院分区：
文献类型：
--
作者：
Mordukhovich I;Wright RO;Hu H;Amarasiriwardena C;Baccarelli A;Litonjua A;Sparrow D;Vokonas P;Schwartz J
背景：流行病学研究表明，砷、镉、汞和铅与心血管疾病有关。这些联系可能是通过金属对血压升高的直接影响来调节的。在职业队列中，锰与心血管功能障碍和低血压有关。目的：我们假设慢性砷、镉、汞和铅暴露会升高血压，而锰会降低血压。方法：我们对来自标准老龄化研究(n=639)的老年男性的趾甲金属与血压的关系进行了横断面分析，使用线性回归并调整了潜在的混杂因素。结果：趾甲砷四分位数范围增加与较高的收缩压[0.93 mm Hg；95%可信区间(CI)：0.25，1.62]和脉压(0.76 mm Hg；95%CI：0.22，1.30)相关。在调整了其他趾甲金属的模型中，砷和BP之间的正关联和锰与BP之间的负关联得到了加强。结论：我们的研究结果表明，血压与砷和锰有关。由于金属暴露和心血管疾病的流行，这可能对公共卫生具有重要意义。考虑到脚趾甲作为金属暴露的生物标志物的潜在局限性，应谨慎地解释结果。
Background: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts. Objectives: We hypothesized that chronic arsenic, cadmium, mercury, and lead exposures elevate BP and that manganese lowers BP. Methods: We conducted a cross-sectional analysis of associations between toenail metals and BP among older men from the Normative Aging Study (n = 639), using linear regression and adjusting for potential confounders. Results: An interquartile range increase in toenail arsenic was associated with higher systolic BP [0.93 mmHg; 95% confidence interval (CI): 0.25, 1.62] and pulse pressure (0.76 mmHg; 95% CI: 0.22, 1.30). Positive associations between arsenic and BP and negative associations between manganese and BP were strengthened in models adjusted for other toenail metals. Conclusions: Our findings suggest associations between BP and arsenic and manganese. This may be of public health importance because of prevalence of both metal exposure and cardiovascular disease. Results should be interpreted cautiously given potential limitations of toenails as biomarkers of metal exposure.
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