Age-related decline in differentiated neural responses to rare target versus frequent standard stimuli.
Age-related decline in differentiated neural responses to rare target versus frequent standard stimuli.
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DOI：
10.1016/j.brainres.2014.08.057
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发表时间：
2014-10-31
期刊：
影响因子：
2.9
通讯作者：
Daffner, Kirk R.
中科院分区：
文献类型：
--
作者：
Mott, Katherine K.;Alperin, Brittany R.;Holcomb, Phillip J.;Daffner, Kirk R.
一个机制假设有助于认知老化是未能招募专门的神经模块，并产生不同的神经反应，以各种类别的刺激。在这里，ERPs被用来检查目标和标准刺激类型在多大程度上被年龄在19-99岁之间的匹配良好的成年人不同的处理。受试者在低负荷和高负荷条件下对指定的视觉目标字母作出反应。时空PCA被用来解析P3 b成分，分类/记忆更新的指标。目标和标准之间的P3 b振幅差异作为年龄的函数大幅下降。去分化始于中年，并持续到老年期。神经反应的分化减少是由与年龄相关的P3 b大小下降到目标和与年龄相关的P3 b增加到标准驱动的。较大的P3 b振幅的标准之间的老年受试者与更高的执行能力和更好的任务表现。总之，去分化在成年期相对较早开始，并在整个生命周期中以线性方式进展。与年龄相关的P3 b增加到标准似乎反映了一种补偿机制，有助于保持任务性能。
One mechanism hypothesized to contribute to cognitive aging is the failure to recruit specialized neural modules and generate differentiated neural responses to various classes of stimuli. Here, ERPs were used to examine the extent to which target and standard stimulus types were processed differently by well-matched adults ages 19–99. Subjects responded to designated visual target letters under low and high load conditions. Temporospatial PCA was used to parse the P3b component, an index of categorization/memory updating. The P3b amplitude difference between targets and standards decreased substantially as a function of age. Dedifferentiation began in middle age, and continued into old-old age. The reduced differentiation of neural responses was driven by an age-related decline in the size of the P3b to targets and an age-related increase in the P3b to standards. Larger P3b amplitude to standards among older subjects was associated with higher executive capacity and better task performance. In summary, dedifferentiation begins relatively early in adulthood and progresses in a linear fashion throughout the lifespan. The age-related augmentation of the P3b to standards appears to reflect a compensatory mechanism that helps maintain task performance.
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影响因子：
3.2
作者：
Daffner KR;Chong H;Sun X;Tarbi EC;Riis JL;McGinnis SM;Holcomb PJ
通讯作者：
Holcomb PJ
影响因子：
2.6
作者：
Curran, T;Hills, A;Strauss, ME
通讯作者：
Strauss, ME
影响因子：
3.7
作者：
Dien, J;Spencer, KM;Donchin, E
通讯作者：
Donchin, E
影响因子：
2.4
作者：
Daffner, Kirk R.;Chong, Hyemi;Holcomb, Phillip J.
通讯作者：
Holcomb, Phillip J.
影响因子：
56.9
作者：
de Fockert, JW;Rees, G;Lavie, N
通讯作者：
Lavie, N