Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms.
Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms.
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DOI：
10.1007/s00018-016-2294-y
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Kadosh D
中科院分区：
文献类型：
--
作者：
Kadosh D
白色念珠菌是一种主要的人类真菌病原体，导致多种免疫功能低下个体的全身和粘膜感染。由于白色念珠菌经历从酵母到细丝的可逆形态转变的能力对于毒力很重要，因此大量的研究工作集中在控制这种转变的机制上。虽然转录和翻译后机制已得到充分研究，但人们对转录后机制的作用知之甚少。然而，近年来，一些发现开始揭示这个重要但尚未得到充分研究的领域。在这里，我将回顾最近被证明可以控制白色念珠菌形态、毒力和/或毒力相关过程的各种转录后机制，包括涉及替代转录本定位、mRNA 稳定性和翻译的机制。我还将讨论这些机制在其他病原体中发挥的作用，以及它们作为新抗真菌策略目标的潜力。最终，更好地了解白色念珠菌转录后机制将显着提高我们对真菌病原体形态发生和毒力如何控制的了解，并为开发新型、更有效的抗真菌药物开辟新途径。
Candida albicans is a major human fungal pathogen responsible for both systemic and mucosal infections in a wide variety of immunocompromised individuals. Because the ability of C. albicans to undergo a reversible morphological transition from yeast to filaments is important for virulence, significant research efforts have focused on mechanisms that control this transition. While transcriptional and post-translational mechanisms have been well-studied, considerably less is known about the role of post-transcriptional mechanisms. However, in recent years several discoveries have begun to shed light on this important, but understudied, area. Here, I will review a variety of post-transcriptional mechanisms that have recently been shown to control C. albicans morphology, virulence and/or virulence-related processes, including those involving alternative transcript localization, mRNA stability and translation. I will also discuss the role that these mechanisms play in other pathogens as well as the potential they may hold to serve as targets for new antifungal strategies. Ultimately, gaining a better understanding of C. albicans post-transcriptional mechanisms will significantly improve our knowledge of how morphogenesis and virulence are controlled in fungal pathogens and open new avenues for the development of novel and more effective antifungals.
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影响因子：
30.3
作者：
Chen C;Pande K;French SD;Tuch BB;Noble SM
通讯作者：
Noble SM
影响因子：
3.6
作者：
Brown, D. H., Jr.;Giusani, A. D.;Chen, X.
通讯作者：
Chen, X.
影响因子：
4.5
作者：
Chacko N;Zhao Y;Yang E;Wang L;Cai JJ;Lin X
通讯作者：
Lin X
影响因子：
--
作者：
Becht, P;Vollmeister, E;Feldbrügge, M
通讯作者：
Feldbrügge, M
DOI：
10.1016/j.bbagrm.2011.08.007
发表时间：
2012-03-01
影响因子：
4.7
作者：
da Rosa, Jessica Lopes;Kaufman, Paul D.
通讯作者：
Kaufman, Paul D.