Retinal Nerve Fibre Layer and Macular Thinning in Spinocerebellar Ataxia and Cerebellar Multisystem Atrophy.
Retinal Nerve Fibre Layer and Macular Thinning in Spinocerebellar Ataxia and Cerebellar Multisystem Atrophy.
复制标题
DOI：
10.3109/01658107.2011.580898
复制
发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Gomez CM
中科院分区：
文献类型：
--
作者：
Pula JH;Towle VL;Staszak VM;Cao D;Bernard JT;Gomez CM
与所有神经退行性疾病一样，脊髓小脑共济失调缺乏客观的疾病和阶段特异性生物标志物。根据一些共济失调患者临床上明显的视盘萎缩或视网膜疾病的报告，以及发现症状前视网膜变薄发生在其他神经系统疾病（如多发性硬化症）中，我们检验了退行性共济失调中可能发生视网膜亚临床神经元或轴突损失的假设。对 29 名经基因证明患有脊髓小脑共济失调 (SCA) 1、2、3 或 6 级或多系统萎缩 C 型 (MSA-C) 的共济失调患者和 27 名年龄匹配的正常受试者进行了谱域光学相干断层扫描。使用共济失调评估和评级量表对共济失调患者进行评估。与正常对照受试者相比，SCA2 和 SCA3 患者的视网膜神经纤维层 (RNFL) 厚度均减少，除 SCA2 之外的所有 SCA 患者黄斑区厚度均减少。
The spinocerebellar ataxias, like all neurodegenerative diseases, lack objective disease- and stage-specific biomarkers. Based on reports of clinically evident optic disc atrophy or retinal disease in some ataxia patients, and the discovery that pre-symptomatic retinal thinning occurs in other neurologic diseases such as multiple sclerosis, we tested the hypothesis that subclinical neuronal or axonal loss in the retina could occur in the degenerative ataxias. Spectral domain optical coherence tomography was performed on 29 ataxia patients with genetically proven spinocerebellar ataxia (SCA) 1, 2, 3, or 6, or multisystem atrophy type C (MSA-C) and 27 age-matched normal subjects. Ataxia patients were assessed using the scale for assessment and rating of ataxia. Compared with normal control subjects, retinal nerve fibre layer (RNFL) thickness was reduced for patients with SCA2 and SCA3, and thickness in the macular region was reduced for all SCAs but SCA2.
登录
查看更多内容
影响因子：
3.5
作者：
Fukutake, T;Kamitsukasa, I;Nakajima, T
通讯作者：
Nakajima, T
影响因子：
3.9
作者：
Blumenthal, E. Z.;Parikh, R. S.;Thomas, R.
通讯作者：
Thomas, R.
影响因子：
2.9
作者：
Iseri, PK;Altinas, Ö;Yüksel, N
通讯作者：
Yüksel, N
影响因子：
14.5
作者：
Abele, M;Bürk, K;Klockgether, T
通讯作者：
Klockgether, T
影响因子：
--
作者：
Buttner, N;Geschwind, D;Baloh, RW
通讯作者：
Baloh, RW