Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties.
Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties.
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DOI：
10.1021/acsami.2c05556
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发表时间：
2022-09-28
影响因子：
9.5
通讯作者：
Sotzing, Gregory A.
中科院分区：
文献类型：
--
作者：
Daniels, Robert;Morato, Erick Orozco;Yassin, Omer A.;Mao, Jiahao;Mutlu, Zeynep;Jain, Mayank;Valenti, Joseph;Cakmak, Mukerrem;Nair, Lakshmi S.;Sotzing, Gregory A.
关键词：
美国大麻种植合法化导致大麻衍生的大麻素价格在两年内下降了10倍。大麻二酚（CBD）是大麻中发现的许多天然存在的二醇之一，可以以高收率低成本纯化，使其成为聚合物原料的有趣候选者。在这项研究中，两个聚酯合成从CBD或大麻萜酚（CBG）与己二酰氯缩合。聚（CBD-己二酸酯）被浇铸成独立的薄膜，并进行热，机械和生物学特性。聚（CBD-己二酸酯）膜表现出缺乏对脂肪来源的干细胞的细胞毒性，同时显示出固有的抗氧化活性相比，聚（丙交酯）膜。此外，发现该材料是半结晶的，并且能够使用硅酮烘焙模具熔融加工成塑料大麻叶。
The legalization of hemp cultivation in the United States has caused the price of hemp-derived cannabinoids to decrease 10-fold within 2 years. Cannabidiol (CBD), one of many naturally occurring diols found in hemp, can be purified in high yield for low cost, making it an interesting candidate for polymer feedstock. In this study, two polyesters were synthesized from the condensation of either CBD or cannabigerol (CBG) with adipoyl chloride. Poly(CBD-Adipate) was cast into free-standing films and subjected to thermal, mechanical, and biological characterization. Poly(CBD-Adipate) films exhibited a lack of cytotoxicity toward adipose-derived stem cells while displaying an inherent antioxidant activity compared to poly(lactide) films. Additionally, this material was found to be semi-crystalline and able to be melt-processed into a plastic hemp leaf using a silicone baking mold.
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DOI：
10.3390/bioengineering7030104
发表时间：
2020-09-02
期刊：
Bioengineering (Basel, Switzerland)
影响因子：
--
作者：
Marrazzo P;O'Leary C
通讯作者：
O'Leary C
影响因子：
4.6
作者：
Iseppi, Ramona;Brighenti, Virginia;Benvenuti, Stefania
通讯作者：
Benvenuti, Stefania
影响因子：
4.6
作者：
Jiang, Fanhui;Cakmak, Miko
通讯作者：
Cakmak, Miko
影响因子：
29.4
作者：
Okamura, Yosuke;Kabata, Koki;Takeoka, Shinji
通讯作者：
Takeoka, Shinji
影响因子：
5
作者：
Maraveas C;Bayer IS;Bartzanas T
通讯作者：
Bartzanas T