Recent Advances in Antioxidant Polymers: From Sustainable and Natural Monomers to Synthesis and Applications.
Recent Advances in Antioxidant Polymers: From Sustainable and Natural Monomers to Synthesis and Applications.
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DOI：
10.3390/polym13152465
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发表时间：
2021-07-27
期刊：
影响因子：
5
通讯作者：
Bartzanas T
中科院分区：
文献类型：
--
作者：
Maraveas C;Bayer IS;Bartzanas T
技术的进步导致了用于食品包装和靶向药物输送应用的可持续抗氧化剂和天然单体的生产。特别重要的是木质素聚合物和接枝聚合物、多巴胺和聚多巴胺、菊粉、槲皮素、柠檬烯和维生素的合成，这是由于它们的自由基清除能力、化学效力、用于聚合的理想官能团、在自然环境中的丰富性、易于生产和生物机制的活化，例如抑制各种信号传导途径的细胞活化，包括NF-κB和MAPK。自由基氧物种负责氧化损伤和增加对癌症、心血管、退行性肌肉骨骼和神经退行性疾病和糖尿病的易感性;这些生物学机制被合成和天然存在的抗氧化剂抑制。在增塑剂存在下，大分子的取向增加了槲皮素在食品包装中的适用性，而萜烯替代现有不可再生聚合物的商业可行性则通过前体（百里香、大麻和柠檬、橙子、柑橘）的可回收性以及边缘生态效应和抗氧化性能得到增强。新兴的抗氧化剂纳米颗粒聚合物在肿瘤靶向药物递送、食品强化、合成聚合物的生物降解以及抗微生物处理和腐蚀抑制方面具有广泛的应用。本文综述了具有内在抗氧化性能的高分子材料的研究进展，包括其合成、清除活性、潜在应用和发展方向。这篇综述不同于其他作品，因为它整合了抗氧化聚合物合成和应用的不同进展，如菊粉，槲皮素聚合物，它们的共轭物，抗氧化剂接枝多糖，聚合维生素和精油。Cirillo和Iemma在2012年发表了关于抗氧化剂聚合物的最全面的综述之一。从那时起，在改进合成、工艺、性能和应用方面取得了重大进展。该综述建立在现有研究的基础上，提出了以前综述中排除的新发现。
Advances in technology have led to the production of sustainable antioxidants and natural monomers for food packaging and targeted drug delivery applications. Of particular importance is the synthesis of lignin polymers, and graft polymers, dopamine, and polydopamine, inulin, quercetin, limonene, and vitamins, due to their free radical scavenging ability, chemical potency, ideal functional groups for polymerization, abundance in the natural environment, ease of production, and activation of biological mechanisms such as the inhibition of the cellular activation of various signaling pathways, including NF-κB and MAPK. The radical oxygen species are responsible for oxidative damage and increased susceptibility to cancer, cardiovascular, degenerative musculoskeletal, and neurodegenerative conditions and diabetes; such biological mechanisms are inhibited by both synthetic and naturally occurring antioxidants. The orientation of macromolecules in the presence of the plasticizing agent increases the suitability of quercetin in food packaging, while the commercial viability of terpenes in the replacement of existing non-renewable polymers is reinforced by the recyclability of the precursors (thyme, cannabis, and lemon, orange, mandarin) and marginal ecological effect and antioxidant properties. Emerging antioxidant nanoparticle polymers have a broad range of applications in tumor-targeted drug delivery, food fortification, biodegradation of synthetic polymers, and antimicrobial treatment and corrosion inhibition. The aim of the review is to present state-of-the-art polymers with intrinsic antioxidant properties, including synthesis scavenging activity, potential applications, and future directions. This review is distinct from other works given that it integrates different advances in antioxidant polymer synthesis and applications such as inulin, quercetin polymers, their conjugates, antioxidant-graft-polysaccharides, and polymerization vitamins and essential oils. One of the most comprehensive reviews of antioxidant polymers was published by Cirillo and Iemma in 2012. Since then, significant progress has been made in improving the synthesis, techniques, properties, and applications. The review builds upon existing research by presenting new findings that were excluded from previous reviews.
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