Autofluorescence of the crystalline lens in early and late onset diabetes.
Autofluorescence of the crystalline lens in early and late onset diabetes.
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早发型和晚发型糖尿病中晶状体的自发荧光。
DOI：
10.1136/bjo.76.1.25
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发表时间：
1992
影响因子：
4.1
通讯作者：
H A Neil
中科院分区：
文献类型：
--
作者：
J M Sparrow;A. J. Bron;N. Brown;H A Neil
在糖尿病患者和对照组的两个群体中，通过体内照相方法研究了晶状体透镜的蓝/绿色自体荧光（在420至430 nm附近激发，在520 nm附近发射）。人群包括一个基于地理位置的幸存者组161混合早发性和迟发性糖尿病患者（和133非糖尿病对照组）和第二组104早发性胰岛素依赖性糖尿病患者（和138非糖尿病对照组），后者都与非白内障晶状体。在两个人群中，糖尿病的存在与晶状体自发荧光增加之间存在强有力的关联（p <10（-6））。在混合型糖尿病患者中，在考虑了年龄和糖尿病病程的影响后，糖尿病类型是一个重要因素。在早发性组（透明镜片）中，考虑到年龄的影响后，自发荧光与糖尿病持续时间之间存在强有力的关联（p = 0.000011），而在晚发性糖尿病患者的透明镜片亚组中，这种影响是适度的（p = 0.015）。在早发性糖尿病组中，在考虑了年龄和糖尿病病程的影响后，糖尿病视网膜病变（p = 0.0064）与晶状体自体荧光增加相关。此外，在该亚组中发现糖尿病病程和糖尿病视网膜病变之间存在强有力的相互作用（p <10（-6））。在以地理位置为基础的糖尿病人群中，在考虑了年龄、糖尿病病程和糖尿病类型的影响后，核褐变的增加与自体荧光的增加密切相关（p <10 - 6）。在非糖尿病人群中未发现这种关联。透镜蛋白的非酶促糖基化应被认为是产生荧光团的可能机制，其发射波长约为520 nm。
Blue/green autofluorescence (excitation around 420 to 430 nm, emission around 520 nm) of the crystalline lens has been studied by an in vivo photographic method in two populations of diabetics and controls. The populations consisted of a geographically based survivor group of 161 mixed early and late onset diabetics (and 133 non-diabetic controls) and a second group of 104 early onset insulin dependent diabetics (and 138 non-diabetic controls), the latter all with non-cataractous lenses. Powerful associations (p less than 10(-6) were found between the presence of diabetes and increased lenticular autofluorescence in both populations. Among the mixed diabetics diabetic type was a significant factor after accounting for the effects of age and diabetic duration. In the early onset group (clear lenses) a powerful association existed between autofluorescence and diabetic duration (p = 0.000011) after allowing for the effect of age, while in a subgroup of late onset diabetics with clear lenses this effect was modest (p = 0.015). In the early onset diabetic group diabetic retinopathy (p = 0.0064) was associated with increased lenticular autofluorescence after allowing for the effects of age and diabetic duration. In addition a powerful interaction between diabetic duration and the presence of diabetic retinopathy (p less than 10(-6) was found in this subgroup. Among the geographically based population of diabetics, increased nuclear brunescence was powerfully associated (p less than 10(-6) with increased autofluorescence after allowing for the effects of age, diabetic duration, and type of diabetes. This association was not found in the non-diabetic population. Non-enzymatic glycosylation of lens proteins should be considered as a possible mechanism of production of the fluorogen with emission around 520 nm.
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DOI：
10.1073/pnas.81.9.2684
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
PONGOR, S;ULRICH, PC;CERAMI, A
通讯作者：
CERAMI, A
晶状体透明度和老化的实验和临床评估。
DOI：
10.1093/geronj/38.3.293
发表时间：
1983
期刊：
Journal of gerontology
影响因子：
--
作者：
Lerman,S
通讯作者：
Lerman,S
人α-晶状体蛋白非酶糖化作用的光谱研究。
影响因子：
4.4
作者：
Liang,JN;ChylackJr,LT
通讯作者：
ChylackJr,LT
人类白内障的摄影和光谱相关性。
影响因子：
2.1
作者：
Lerman,S;Moran,M;Matthews,N
通讯作者：
Matthews,N
影响因子：
1.9
作者：
ROSNER, B
通讯作者：
ROSNER, B