Sex differences in Alzheimer's disease: do differences in tau explain the verbal memory gap?
Sex differences in Alzheimer's disease: do differences in tau explain the verbal memory gap?
复制标题
DOI：
10.1016/j.neurobiolaging.2021.05.013
复制
发表时间：
2021-11
影响因子：
4.2
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Banks SJ;Andrews MJ;Digma L;Madsen J;Reas ET;Caldwell JZK;McEvoy LK;Fan CC;Dale AM;Brewer JB;Alzheimer's Disease Neuroimaging Initiative
为了确定AD患者言语记忆的性别差异是否与病理性tau的程度或分布的差异有关，我们研究了275名淀粉样蛋白PET阳性的参与者，他们进行了正常认知、轻度认知障碍(MCI)或痴呆的临床分类，并患有tau(AV1451)PET。我们比较了tau在男性和女性之间的分布，以及作为遗传风险的函数。在MCI中，我们进一步探讨了tau的数量和分布与言语记忆成绩的关系。女性总体上有更多的tau负担，但这是由MCI阶段的性别差异推动的。ApoE e4状态对tau载量的影响无显著差异。在MCI组中，tau与言语记忆任务中的表现之间的关联在女性中比男性更强。Tau和言语记忆之间的联系在MCI中也不同；女性在tau分布和言语记忆表现之间表现出更强的关系，特别是在左半球。这些发现对于理解tau的分布和扩散，以及解释言语记忆的表现都有一定的意义。
To determine if sex differences in verbal memory in AD are related to differences in extent or distribution of pathological tau, we studied 275 participants who were amyloid PET positive and carried clinical classifications of normal cognition, mild cognitive impairment (MCI) or dementia, and had tau (AV1451) PET. We compared tau distribution between men and women, and as a function of genetic risk. In MCI we further explored the relationship between quantity and distribution of tau in relation to verbal memory scores. Women had more tau burden overall, but this was driven by sex differences at the MCI stage. There was no significant difference in tau load by APOE e4 status. Within the MCI group the association between tau and performance in verbal memory tasks was stronger in women than men. The topography of the associations between tau and verbal memory also differed in MCI; women demonstrated stronger relationships between tau distribution and verbal memory performance, especially in the left hemisphere. These findings have implications for understanding tau distribution and spread, and in interpretation of verbal memory performance.
登录
查看更多内容
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1016/j.jalz.2018.04.010
发表时间：
2018-09
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Buckley RF;Mormino EC;Amariglio RE;Properzi MJ;Rabin JS;Lim YY;Papp KV;Jacobs HIL;Burnham S;Hanseeuw BJ;Doré V;Dobson A;Masters CL;Waller M;Rowe CC;Maruff P;Donohue MC;Rentz DM;Kirn D;Hedden T;Chhatwal J;Schultz AP;Johnson KA;Villemagne VL;Sperling RA;Alzheimer's Disease Neuroimaging Initiative;Australian Imaging, Biomarker and Lifestyle study of ageing;Harvard Aging Brain Study
通讯作者：
Harvard Aging Brain Study
DOI：
10.1007/s00259-014-2753-3
发表时间：
2014-07
影响因子：
9.1
作者：
Landau, S. M.;Thomas, B. A.;Thurfjell, L.;Schmidt, M.;Margolin, R.;Mintun, M.;Pontecorvo, M.;Baker, S. L.;Jagust, W. J.
通讯作者：
Jagust, W. J.
DOI：
10.1186/s13195-017-0300-8
发表时间：
2017-09-12
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Caldwell JZK;Berg JL;Cummings JL;Banks SJ;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
DOI：
10.1186/s13195-020-00712-4
发表时间：
2020-11-04
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Emrani S;Arain HA;DeMarshall C;Nuriel T
通讯作者：
Nuriel T