Comparison of effects of the ethanolic extracts of brazilian propolis on human leukemic cells as assessed with the MTT assay.
Comparison of effects of the ethanolic extracts of brazilian propolis on human leukemic cells as assessed with the MTT assay.
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DOI：
10.1155/2012/918956
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Park YK
中科院分区：
文献类型：
--
作者：
Franchi GC Jr;Moraes CS;Toreti VC;Daugsch A;Nowill AE;Park YK
蜂胶是蜜蜂采集的一种树脂产品。也有报道称，蜂胶具有广泛的生物活性，包括抗菌活性和抗氧化、抗炎、抑制二恶英毒性等活性。本研究的目的是比较绿蜂胶(G12)和红蜂胶(G13)对人白血病细胞的体外杀伤活性。将这些细胞与不同浓度的蜂胶孵育，48小时后计算每个细胞的IC50。结果表明，红蜂胶的体外细胞毒作用高于绿蜂胶。红蜂胶对K562细胞具有细胞抑制作用，并能诱导与其对照格列卫相同数量的细胞凋亡率。综上所述，这些结果表明，在多种人类白血病细胞系中，红色蜂胶比绿色蜂胶具有更强的细胞毒性。红色蜂胶可能含有能够抑制癌细胞生长的药物。因此，进一步从红蜂胶(G13)中分离出各自的化学成分以鉴定其活性是必要的。
Propolis is a resinous product collected by honey bees. It was also reported that propolis has a wide variety of biological actions, including antimicrobial activity and antioxidant, anti-inflammatory, and suppressive effects of dioxin toxicity activities. The aim of this study was to compare the in vitro cytotoxic activities of green propolis (G12) and red propolis (G13) in human leukemia cells. These cells were incubated with different concentrations of propolis and 48 hours after the IC50 was calculated for each cell. The results showed that the red propolis has cytotoxic effect in vitro higher than green propolis. Red propolis was showed to be cytostatic in K562 cells and caused the same amount of apoptosis as its control Gleevec. In conclusion, these results showed that red propolis is more cytotoxic than the green propolis in a variety of human cell lines of leukemia. Red propolis may contain drugs capable of inhibiting cancer cell growth. Therefore, further isolation of respective chemical ingredients from the red propolis (G13) for identification of the activities is necessary.
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影响因子：
6.1
作者：
Park, YK;Fukuda, I;Pastore, GM
通讯作者：
Pastore, GM
影响因子：
20.3
作者：
LOZZIO, CB;LOZZIO, BB
通讯作者：
LOZZIO, BB
DOI：
10.1080/0005772x.1990.11099047
发表时间：
1990-01-01
期刊：
BEE WORLD
影响因子：
--
作者：
GREENAWAY, W;SCAYSBROOK, T;WHATLEY, FR
通讯作者：
WHATLEY, FR
影响因子：
2.6
作者：
Park, YK;Koo, MH;Rosalen, PL
通讯作者：
Rosalen, PL
影响因子：
4.6
作者：
KLEIN, G;GIOVANELLA, B;MUMFORD, D
通讯作者：
MUMFORD, D