Microstimulation reveals limits in detecting different signals from a local cortical region.
Microstimulation reveals limits in detecting different signals from a local cortical region.
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DOI：
10.1016/j.cub.2010.02.065
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发表时间：
2010-05-11
期刊：
影响因子：
--
通讯作者：
Maunsell JH
中科院分区：
文献类型：
--
作者：
Ni AM;Maunsell JH
行为表现取决于感觉皮层神经元的活动，但人们对大脑获取特定神经元信号以指导行为的能力知之甚少。即使是对相关刺激最敏感的单个感觉神经元也与行为只有微弱的相关性，这表明行为决策是基于敏感性与任务要求相匹配的神经元组的组合活动。为了探索如何灵活地从一个给定的皮层区域访问不同的活动模式，我们训练动物检测局部V1部位的电微刺激。通过让动物成为检测特定V1位点微刺激的专家，这些位点对应于特定的视网膜位置，我们可以测量训练对这些位点支持视觉刺激检测能力的影响。检测电激活的训练引起了检测视觉刺激的阈值的大的、可逆的、视网膜定位的损伤。视觉检测的再训练恢复了正常阈值，反过来又损害了检测微刺激的阈值。这些结果表明，有实质性的限制的类型的信号，局部皮层区域可以同时优化。
Behavioral performance depends on the activity of neurons in sensory cortex, but little is known about the brain's capacity to access specific neuronal signals to guide behavior. Even the individual sensory neurons that are most sensitive to a relevant stimulus are only weakly correlated with behavior, suggesting that behavioral decisions are based on the combined activity of groups of neurons with sensitivities well matched to task demands. To explore how flexibly different patterns of activity can be accessed from a given cortical region, we trained animals to detect electrical microstimulation of local V1 sites. By allowing the animals to become expert at the detection of microstimulation of specific V1 sites that corresponded to particular retinotopic locations, we could measure the effects of that training on the ability of those sites to support the detection of visual stimuli. Training to detect electrical activation caused a large, reversible, retinotopically-localized impairment of thresholds for detecting visual stimuli. Retraining on visual detection restored normal thresholds, and in turn impaired thresholds for detecting microstimulation. These results suggest that there are substantial limits to the types of signals for which a local cortical region can be simultaneously optimized.
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DOI：
10.1073/pnas.0501026102
发表时间：
2005-06-21
影响因子：
11.1
作者：
Seitz, AR;Nanez, JE;Watanabe, T
通讯作者：
Watanabe, T
影响因子：
64.8
作者：
KARNI, A;SAGI, D
通讯作者：
SAGI, D
DOI：
10.3758/bf03202828
发表时间：
1983-01-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
WATSON, AB;PELLI, DG
通讯作者：
PELLI, DG
影响因子：
2.5
作者：
DeYoe, EA;Lewine, JD;Doty, RW
通讯作者：
Doty, RW
影响因子：
2
作者：
Tehovnik, EJ;Slocum, WM
通讯作者：
Slocum, WM