GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration.
GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration.
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DOI：
10.1111/exd.14526
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发表时间：
2022-04
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
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我们提出GDNF，一种胶质细胞系源性神经营养因子，可以通过指导真皮成纤维细胞的命运来促进毛囊新生和创伤后皮肤再生。我们的假设主要基于皮肤再生阶段的详细GDNF和受体分析，以及在促再生多刺小鼠（Acomys属）及其再生较少的后代家鼠（Mus musculus）之间受伤后GDNF受体的诱导。为了表征GDNF靶细胞，我们将结合单细胞RNA和转座酶可及染色质测序实验进行一系列谱系追踪实验。皮肤再生的异质动力学尚未完全确定，这项研究将有助于推进再生医学和生物学领域。最后，我们相信，刺激来自再生较少的动物（如人类）的成纤维细胞中的GDNF信号通路，将促进皮肤再生，形态发生和无瘢痕伤口愈合。
We propose that GDNF, a glial cell line‐derived neurotrophic factor, can promote hair follicle neogenesis and skin regeneration after wounding by directing the fate of dermal fibroblasts. Our hypothesis is largely based on detailed GDNF and receptor analysis during skin regenerative stages, as well as the induction of GDNF receptors after wounding between the pro‐regenerative spiny mouse (genus Acomys) and its less‐regenerative descendant, the house mouse (Mus musculus). To characterize the GDNF‐target cells, we will conduct a series of lineage‐tracing experiments in conjunction with single‐cell RNA and assay for transposase‐accessible chromatin sequencing experiments. The heterogenetic dynamics of skin regeneration have yet to be fully defined, and this research will help to advance the fields of regenerative medicine and biology. Finally, we believe that stimulating the GDNF signalling pathway in fibroblasts from less‐regenerative animals, such as humans, will promote skin regeneration, morphogenesis and scarless wound healing.
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影响因子：
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作者：
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通讯作者：
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