Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab
Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab
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雷珠单抗治疗伴有黄斑水肿的视网膜分支静脉阻塞时，通过激光散斑血流成像和光学相干断层扫描血管造影测量眼部微循环变化
DOI：
10.1007/s10792-020-01562-7
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发表时间：
2020
影响因子：
1.6
通讯作者：
Nakazawa Toru
中科院分区：
文献类型：
--
作者：
Asano Toshifumi;Kunikata Hiroshi;Yasuda Masayuki;Nishiguchi Koji M.;Abe Toshiaki;Nakazawa Toru
PurposeThis study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by分支视网膜静脉阻塞（BRVOME）. Methods24眼24例BRVOME患者玻璃体内注射雷珠单抗（IVR）治疗至少6个月。结果IVR后6个月最佳矫正视力（BCVA）与年龄、IVR前BCVA、IVR后1个月BCVA、IVR后3个月BCVA及IVR前收缩压呈正相关与IVR前总MBR、IVR后1个月总MBR、IVR后6个月总MBR、IVR后3个月视网膜深毛细血管丛（DCP）VD和IVR后6个月DCP VD均呈负相关（分别为P<0.001，P <0.001，P < 0.001和P = 0.02（P= 0.03，P = 0.03，P = 0.02，P = 0.01，P = 0.005）。此外，多元回归分析显示，IVR前总体MBR（β = − 0.67，P = 0.009）是预测IVR后6个月BCVA的独立预后因素。6个月后的IVR DCP VD也与整体MBR在所有的时间points.ConclusionONH血流量可能是一个前IVR的生物标志物的视觉效果和后IVR深黄斑微循环的眼睛BRVOME。
PurposeThis study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME).MethodsTwenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively.ResultsSix-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure (P< 0.001,P< 0.001,P< 0.001,P< 0.001 andP= 0.02, respectively) and negatively with pre-IVR overall MBR, 1-month post-IVR overall MBR, 6-month post-IVR overall MBR, 3-month post-IVR deep retinal capillary plexus (DCP) VD and 6-month post-IVR DCP VD (P= 0.03,P= 0.03,P= 0.02,P= 0.01 andP= 0.005, respectively). Furthermore, a multiple regression analysis showed that pre-IVR overall MBR (β = − 0.67,P= 0.009) was among independent prognostic factors predicting 6-month post-IVR BCVA. Six-month post-IVR DCP VD was also correlated with overall MBR at all time points.ConclusionONH blood flow may be a pre-IVR biomarker of both visual outcomes and post-IVR deep macular microcirculation in eyes with BRVOME.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
4.4
作者：
Nagahara, Miyuki;Tamaki, Yasuhiro;Araie, Makoto
通讯作者：
Araie, Makoto
与视网膜分支静脉阻塞相关的黄斑水肿的治疗：美国眼科学会的报告。
DOI：
--
发表时间：
2015
期刊：
Ophthalmology (Rochester, Minn.)
影响因子：
--
作者：
Justis P. Ehlers;Stephen J. Kim;S. Yeh;J. Thorne;P. Mruthyunjaya;S. Schoenberger;S. Bakri
通讯作者：
S. Bakri
影响因子：
13.7
作者：
Yeh, Steven;Kim, Stephen J.;Thorne, Jennifer E.
通讯作者：
Thorne, Jennifer E.