Proximity to sources of airborne lead is associated with reductions in Children's executive function in the first four years of life.

Proximity to sources of airborne lead is associated with reductions in Children's executive function in the first four years of life.
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接近空气中铅的来源与儿童在生命的前四年执行功能的减少有关。

DOI:
10.1016/j.healthplace.2021.102517
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发表时间:
2021-03
期刊:
影响因子:
4.8
通讯作者:
Blair C
Blair C
中科院分区:
医学2区
文献类型:
--
作者:
Gatzke-Kopp LM;Warkentien S;Willoughby M;Fowler C;Folch DC;Blair C

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虽然从汽油中去除铅的政策已经导致空气中铅的大量减少,但已知多个行业会产生释放到空气中的铅。本研究探讨在何种程度上住宅接近空气中的铅的记录源与儿童的智力和执行功能。来自家庭生活项目的n = 849名儿童的数据可用。出生到36个月之间儿童住所的地理位置参考了环境保护局的风险筛选环境指标(RSEI)数据库,该数据库估计了美国本土每半英里网格的暴露量。工具变量模型被用来估计在36个月,48个月和60个月测量的暴露和认知结果之间的因果关系,使用人口普查记录的制造业就业密度作为工具。模型的连续铅剂量表明小的负面影响,儿童智商和执行功能(EF)。这些结果表明,RSEI估计空气中的铅暴露与认知发展的递减有意义的。
Although policies to remove lead from gasoline have resulted in a substantial reduction in airborne lead, multiple industries are known to generate lead that is released in the air. The present study examines the extent to which residential proximity to a documented source of airborne lead is associated with intellectual and executive function in children. Data were available for n = 849 children from the Family Life Project. Geolocation for children’s residences between birth and 36 months were referenced against the Environmental Protection Agency’s Risk Screening Environmental Indicators (RSEI) database, which estimates exposure for each ½ mile grid in the contiguous United States. Instrumental variable models were employed to estimate causal associations between exposure and cognitive outcomes measured at 36, 48, and 60 months, using census-documented density of manufacturing employment as the instrument. Models of continuous lead dosage indicated small negative effects for both child IQ and executive function (EF). These results indicate that RSEI estimates of airborne lead exposure are meaningfully associated with decrements in cognitive development.
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