Pre-vaccination nasopharyngeal pneumococcal carriage in a Nigerian population: epidemiology and population biology.
Pre-vaccination nasopharyngeal pneumococcal carriage in a Nigerian population: epidemiology and population biology.
复制标题
尼日利亚人口中的鼻咽前肺炎球菌：流行病学和人口生物学。
DOI：
10.1371/journal.pone.0030548
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Adegbola RA
中科院分区：
文献类型：
--
作者：
Adetifa IM;Antonio M;Okoromah CA;Ebruke C;Inem V;Nsekpong D;Bojang A;Adegbola RA
在尼日利亚引进肺炎球菌疫苗是全球疫苗和免疫联盟（免疫联盟）加速疫苗引进倡议的一个优先事项。然而，关于肺炎球菌疾病（IPD）负担的国家数据有限，可用结合疫苗的覆盖率未知。这项研究的目的是描述尼日利亚肺炎球菌携带的疫苗接种前流行病学和群体生物学。这是一项横向调查。鼻咽拭子（鼻咽拭子）从14个相邻的尼日利亚城郊社区的人群样本中获得。从所有研究参与者中获得了关于人口统计学特征和携带风险因素的数据。肺炎双球菌分离的特点是血清分型，抗菌药物的敏感性和多位点测序分型（MLST）。肺炎球菌携带率为52.5%。儿童的携带率高于成人（67.4%比26%），最高（约90%）发生在9个月以下的婴儿中，并随年龄的增长而显著降低（P<0.001）。血清型以19 F（18.6%）和6A（14.4%）为主。PCV-7、PCV-10和PCV-13的潜在疫苗接种率分别为43.8%、45.0%和62%。有16个新的等位基因，72个不同的序列类型（ST）的分离株和3个序列类型（280，310和5543）与分离株的一个以上的血清型指示血清型转换。复方新诺明（93%）和四环素（84%）耐药率较高，三分之一的菌株对青霉素有中度耐药。年轻是与携带显著相关的唯一风险因素。肺炎球菌携带和血清型多样性在尼日利亚非常普遍，特别是在婴儿中。基于本研究中血清型的覆盖率，PCV-13是降低疾病负担和耐药肺炎球菌流行的明显选择。然而，其使用将需要仔细监测。我们的研究结果为尼日利亚引入疫苗后的影响评估提供了可靠的基线数据。
Introduction of pneumococcal vaccines in Nigeria is a priority as part of the Accelerated Vaccine Introduction Initiative (AVI) of the Global Alliance for Vaccines and Immunisation (GAVI). However, country data on the burden of pneumococcal disease (IPD) is limited and coverage by available conjugate vaccines is unknown. This study was carried out to describe the pre vaccination epidemiology and population biology of pneumococcal carriage in Nigeria. This was a cross sectional survey. Nasopharyngeal swabs (NPS) were obtained from a population sample in 14 contiguous peri-urban Nigerian communities. Data on demographic characteristics and risk factor for carriage were obtained from all study participants. Pneumococci isolated from NPS were characterised by serotyping, antimicrobial susceptibility and Multi Locus Sequencing Typing (MLST). The prevalence of pneumococcal carriage was 52.5%. Carriage was higher in children compared to adults (67.4% vs. 26%), highest (≈90%) in infants aged <9 months and reduced significantly with increasing age (P<0.001). Serotypes 19F (18.6%) and 6A (14.4%) were most predominant. Potential vaccine coverage was 43.8%, 45.0% and 62% for PCV-7, PCV-10 and PCV-13 respectively. There were 16 novel alleles, 72 different sequence types (STs) from the isolates and 3 Sequence Types (280, 310 and 5543) were associated with isolates of more than one serotype indicative of serotype switching. Antimicrobial resistance was high for cotrimoxazole (93%) and tetracycline (84%), a third of isolates had intermediate resistance to penicillin. Young age was the only risk factor significantly associated with carriage. Pneumococcal carriage and serotype diversity is highly prevalent in Nigeria especially in infants. Based on the coverage of serotypes in this study, PCV-13 is the obvious choice to reduce disease burden and prevalence of drug resistant pneumococci. However, its use will require careful monitoring. Our findings provide sound baseline data for impact assessment following vaccine introduction in Nigeria.
登录
查看更多内容
影响因子：
3.6
作者：
Farrell, David J.;Klugman, Keith P.;Pichichero, Michael
通讯作者：
Pichichero, Michael
影响因子：
3.6
作者：
BLOCK, SL;HARRISON, CJ;CHARTRAND, SA
通讯作者：
CHARTRAND, SA
影响因子：
6.4
作者：
GRAY, BM;CONVERSE, GM;DILLON, HC
通讯作者：
DILLON, HC
影响因子：
3.6
作者：
Feikin, DR;Davis, M;Dowell, SF
通讯作者：
Dowell, SF
影响因子：
11.8
作者：
Hill, Philip C.;Townend, John;Adegbola, Richard A.
通讯作者：
Adegbola, Richard A.