Using mechanistic models to highlight research priorities for tick-borne zoonotic diseases: Improving our understanding of the ecology and maintenance of Kyasanur Forest Disease in India
Using mechanistic models to highlight research priorities for tick-borne zoonotic diseases: Improving our understanding of the ecology and maintenance of Kyasanur Forest Disease in India
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使用机制模型突出蜱传人畜共患疾病的研究重点：提高我们对印度 Kyasanur 森林病害的生态和维护的了解
DOI：
10.1101/2022.10.17.512427
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hassall R
中科院分区：
文献类型：
--
作者：
Hassall R
人畜共患病向人类蔓延的风险正在因多种环境和社会驱动因素而发生变化，特别是在热带地区，那里被忽视的人畜共患病的负担最重，土地使用变化和森林转换发生得最快。被忽视的人畜共患病可能对资源匮乏环境中的贫困和边缘化人口产生重大影响，但最终得到的关注和研究及干预资金较少。因此，有效的控制措施和干预措施往往受到生态证据基础有限的阻碍，这导致对流行病学相关宿主或病媒以及有助于病原体维持和向人类外溢的过程的了解有限。在这里，我们开发了一个可推广的下一代矩阵建模框架，以更好地了解对蜱传疾病的维持贡献最大的传播过程和宿主，旨在改善生态证据基础，并制定未来的研究重点蜱传疾病。使用这个模型，我们探讨了不同的主机组和传播途径的相对贡献，以维护一个被忽视的人畜共患蜱传疾病，Kyasanur森林病病毒（KFD），在多个栖息地类型。研究结果强调了跨卵传播和小型哺乳动物和鸟类在维持这种疾病方面的潜在重要性。这与先前的假设相矛盾，即灵长类动物在影响受感染蜱虫的分布方面发挥着重要作用。还有一种观点认为，不同的栖息地类型可能存在不同的风险，但目前需要更多的研究来评估这种关系。根据这些结果，我们概述了该系统的关键知识差距和未来的研究重点，可以为有效的干预和控制措施提供信息。
The risk of spillover of zoonotic diseases to humans is changing in response to multiple environmental and societal drivers, particularly in tropical regions where the burden of neglected zoonotic diseases is highest and land use change and forest conversion is occurring most rapidly. Neglected zoonotic diseases can have significant impacts on poor and marginalised populations in low-resource settings but ultimately receive less attention and funding for research and interventions. As such, effective control measures and interventions are often hindered by a limited ecological evidence base, which results in a limited understanding of epidemiologically relevant hosts or vectors and the processes that contribute to the maintenance of pathogens and spillover to humans. Here, we develop a generalisable next generation matrix modelling framework to better understand the transmission processes and hosts that have the greatest contribution to the maintenance of tick-borne diseases with the aim of improving the ecological evidence base and framing future research priorities for tick-borne diseases. Using this model we explore the relative contribution of different host groups and transmission routes to the maintenance of a neglected zoonotic tick-borne disease, Kyasanur Forest Disease Virus (KFD), in multiple habitat types. The results highlight the potential importance of transovarial transmission and small mammals and birds in maintaining this disease. This contradicts previous hypotheses that primates play an important role influencing the distribution of infected ticks. There is also a suggestion that risk could vary across different habitat types but currently more research is needed to evaluate this relationship. In light of these results, we outline the key knowledge gaps for this system and future research priorities that could inform effective interventions and control measures.
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DOI：
10.1017/9781316711644.011
发表时间：
2019-05
期刊：
Rates of Evolution
影响因子：
--
作者：
Hersholt C. Waxman;Margaret C. Wang;Kenneth A. Anderson;Herbert J. Walberg;Heraholt C. Waxman
通讯作者：
Hersholt C. Waxman;Margaret C. Wang;Kenneth A. Anderson;Herbert J. Walberg;Heraholt C. Waxman
Kyasanur 森林病：印度的流行病学观点
影响因子：
11.1
作者：
Priyabrata Pattnaik
通讯作者：
Priyabrata Pattnaik
西高止山脉栖息地对鸟类群落的热情好客
DOI：
--
发表时间：
1997
期刊：
影响因子：
--
作者：
P. Pramod;N. Joshi;U. Ghate;M. Gadgil
通讯作者：
M. Gadgil
影响因子：
2.5
作者：
Mewa Singh;N. Raghunatha Rao
通讯作者：
N. Raghunatha Rao
Kyasanur 森林病病毒在刺血蜱中的实验性跨卵巢传播
影响因子：
64.8
作者：
K. Singh;K. Pavri;C. R. Anderson
通讯作者：
C. R. Anderson