Non-coding RNAs and retroviruses.
Non-coding RNAs and retroviruses.
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DOI：
10.1186/s12977-018-0403-8
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发表时间：
2018-02-09
期刊：
影响因子：
3.3
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Zhang X;Ma X;Jing S;Zhang H;Zhang Y
Retroviruses can cause severe diseases such as cancer and acquired immunodeficiency syndrome. A unique feature in the life cycle of retroviruses is that their RNA genome is reverse transcribed into double-stranded DNA, which then integrates into the host genome to exploit the host machinery for their benefits. The metazoan genome encodes numerous non-coding RNAs (ncRNA), which act as key regulators in essential cellular processes such as antiviral response. The development of next-generation sequencing technology has greatly accelerated the detection of ncRNAs from viruses and their hosts. ncRNAs have been shown to play important roles in the retroviral life cycle and virus–host interactions. Here, we review recent advances in ncRNA studies with special focus on those have changed our understanding of retroviruses or provided novel strategies to treat retrovirus-related diseases. Many ncRNAs such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are involved in the late phase of the retroviral life cycle. However, their roles in the early phase of viral replication merit further investigations.
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DOI：
10.1261/rna.057299.116
发表时间：
2016-08
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Eckwahl MJ;Arnion H;Kharytonchyk S;Zang T;Bieniasz PD;Telesnitsky A;Wolin SL
通讯作者：
Wolin SL
影响因子：
4.8
作者：
Cherepanov, P;Maertens, G;Debyser, Z
通讯作者：
Debyser, Z
影响因子：
5.4
作者：
Budhiraja, Sona;Liu, Hongbing;Rice, Andrew P.
通讯作者：
Rice, Andrew P.
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
DOI：
10.1073/pnas.94.24.13193
发表时间：
1997-11-25
影响因子：
11.1
作者：
Chun, TW;Stuyver, L;Fauci, AS
通讯作者：
Fauci, AS