Role of Decidual Natural Killer Cells in Human Pregnancy and Related Pregnancy Complications.
Role of Decidual Natural Killer Cells in Human Pregnancy and Related Pregnancy Complications.
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DOI：
10.3389/fimmu.2021.728291
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发表时间：
2021
影响因子：
7.3
通讯作者：
Wei H
中科院分区：
文献类型：
--
作者：
Zhang X;Wei H
怀孕是一种独特的免疫过程。健康妊娠与一系列炎症事件相关：着床（炎症）、妊娠（抗炎症）和分娩（炎症）。自然杀伤细胞（natural killer， NK）是妊娠期最丰富的白细胞，通过卵巢激素的募集和激活，在妊娠期起着举足轻重的作用。在妊娠早期，NK细胞占蜕膜淋巴细胞的50-70%。与外周血NK细胞不同，蜕膜自然杀伤（dNK）细胞的细胞溶解能力较差，它们释放细胞因子/趋化因子，诱导滋养细胞侵袭、组织重塑、胚胎发育和胎盘。如果NK细胞在子宫内被病原体感染，也可以转变为细胞毒性并进行免疫防御。在妊娠后期，NK细胞的过早激活可导致母胎界面耐受性的破坏，随后可导致早产。本文综述了dNK细胞在正常妊娠和病理性妊娠中的作用，包括先兆子痫、复发性自然流产、子宫内膜异位症和复发性植入失败。dNK细胞可能成为治疗妊娠并发症的靶点。
Pregnancy is a unique type of immunological process. Healthy pregnancy is associated with a series of inflammatory events: implantation (inflammation), gestation (anti-inflammation), and parturition (inflammation). As the most abundant leukocytes during pregnancy, natural killer (NK) cells are recruited and activated by ovarian hormones and have pivotal roles throughout pregnancy. During the first trimester, NK cells represent up to 50–70% of decidua lymphocytes. Differently from peripheral-blood NK cells, decidual natural killer (dNK) cells are poorly cytolytic, and they release cytokines/chemokines that induce trophoblast invasion, tissue remodeling, embryonic development, and placentation. NK cells can also shift to a cytotoxic identity and carry out immune defense if infected in utero by pathogens. At late gestation, premature activation of NK cells can lead to a breakdown of tolerance of the maternal–fetal interface and, subsequently, can result in preterm birth. This review is focused on the role of dNK cells in normal pregnancy and pathological pregnancy, including preeclampsia, recurrent spontaneous abortion, endometriosis, and recurrent implantation failure. dNK cells could be targets for the treatment of pregnancy complications.
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DOI：
10.1038/nrneph.2014.102
发表时间：
2014-08
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
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通讯作者：
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