Diversity and Epidemiology of Bat Trypanosomes: A One Health Perspective.
Diversity and Epidemiology of Bat Trypanosomes: A One Health Perspective.
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DOI：
10.3390/pathogens10091148
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发表时间：
2021-09-06
期刊：
影响因子：
--
通讯作者：
Barbosa AD
中科院分区：
文献类型：
--
作者：
Austen JM;Barbosa AD
蝙蝠(翼手目)越来越多地被认为是世界各地人类和动物病原体的重要宿主。在这种背景下，迄今为止基于分子和显微镜的研究揭示了锥虫属的高度多样性。蝙蝠的庇护所，包括公认的医疗和兽医重要物种，如克氏锥虫和伊氏锥虫(分别是恰加斯病和苏拉氏病的病原体)。本文根据分子研究和形态记录，对蝙蝠锥虫的多样性、分类学、进化和流行病学等方面的研究现状进行了综述。此外，我们使用一个健康的方法来讨论蝙蝠作为克鲁兹毛滴虫的宿主(和假定的媒介)的重要性，重点是物种内遗传多样性和科尔瓦夫和家养生态系统中克鲁兹毛滴虫的生态流行病学之间的复杂关联。这篇文章还强调了目前关于单一宿主中锥虫联合感染的生物学影响以及迄今记录的大多数蝙蝠锥虫的流行率、媒介、生命周期、宿主范围和临床影响的知识空白。为了改进疾病预防和控制，减轻生物安全风险和潜在的溢出事件，最终确保全球人类、家畜和野生动物的健康，需要持续开展涉及蝙蝠锥体分子监测的研究工作。
Bats (order Chiroptera) have been increasingly recognised as important reservoir hosts for human and animal pathogens worldwide. In this context, molecular and microscopy-based investigations to date have revealed remarkably high diversity of Trypanosoma spp. harboured by bats, including species of recognised medical and veterinary importance such as Trypanosoma cruzi and Trypanosoma evansi (aetiological agents of Chagas disease and Surra, respectively). This review synthesises current knowledge on the diversity, taxonomy, evolution and epidemiology of bat trypanosomes based on both molecular studies and morphological records. In addition, we use a One Health approach to discuss the significance of bats as reservoirs (and putative vectors) of T. cruzi, with a focus on the complex associations between intra-specific genetic diversity and eco-epidemiology of T. cruzi in sylvatic and domestic ecosystems. This article also highlights current knowledge gaps on the biological implications of trypanosome co-infections in a single host, as well as the prevalence, vectors, life-cycle, host-range and clinical impact of most bat trypanosomes recorded to date. Continuous research efforts involving molecular surveillance of bat trypanosomes are required for improved disease prevention and control, mitigation of biosecurity risks and potential spill-over events, ultimately ensuring the health of humans, domestic animals and wildlife globally.
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影响因子：
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