A need for NAD+ in muscle development, homeostasis, and aging.
A need for NAD+ in muscle development, homeostasis, and aging.
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DOI：
10.1186/s13395-018-0154-1
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发表时间：
2018-03-07
期刊：
影响因子：
4.9
通讯作者：
Henry CA
中科院分区：
文献类型：
--
作者：
Goody MF;Henry CA
骨骼肌使姿势，呼吸和运动。骨骼肌还影响全身过程，如新陈代谢，体温调节和免疫力。骨骼肌能量昂贵，是葡萄糖和脂肪酸的主要消耗者。脂肪酸和葡萄糖的代谢需要NAD+作为氢/电子转移分子。因此，NAD+在能源生产中起着至关重要的作用。此外，NAD+还作为翻译后修饰如脱乙酰化和ADP-核糖基化的共底物发挥作用。因此，NAD+水平影响无数的细胞过程，包括线粒体生物发生、转录和细胞外基质的组织。显然，NAD+是骨骼肌发育，再生，衰老和疾病的主要参与者。绝大多数研究表明，较低的NAD+水平对肌肉健康有害，较高的NAD+水平可增强肌肉健康。然而，NAD+在整个不同细胞区室中的功能的下游机制还没有很好地理解。这篇综述的目的是强调最近的研究调查NAD+在肌肉发育，稳态，疾病和再生中的功能。新兴的研究领域包括阐明NAD+在肌肉溶酶体功能和钙动员中的作用，肌肉发育和再生过程中控制NAD+水平波动的机制，以及NAD+信号传导靶点（特别是线粒体和细胞外基质）之间的相互作用。这些知识应该有助于确定更精确的药理学和基于活动的干预措施，以提高骨骼肌中的NAD+水平，从而促进人类在正常和疾病状态下的健康和功能。
Skeletal muscle enables posture, breathing, and locomotion. Skeletal muscle also impacts systemic processes such as metabolism, thermoregulation, and immunity. Skeletal muscle is energetically expensive and is a major consumer of glucose and fatty acids. Metabolism of fatty acids and glucose requires NAD+ function as a hydrogen/electron transfer molecule. Therefore, NAD+ plays a vital role in energy production. In addition, NAD+ also functions as a cosubstrate for post-translational modifications such as deacetylation and ADP-ribosylation. Therefore, NAD+ levels influence a myriad of cellular processes including mitochondrial biogenesis, transcription, and organization of the extracellular matrix. Clearly, NAD+ is a major player in skeletal muscle development, regeneration, aging, and disease. The vast majority of studies indicate that lower NAD+ levels are deleterious for muscle health and higher NAD+ levels augment muscle health. However, the downstream mechanisms of NAD+ function throughout different cellular compartments are not well understood. The purpose of this review is to highlight recent studies investigating NAD+ function in muscle development, homeostasis, disease, and regeneration. Emerging research areas include elucidating roles for NAD+ in muscle lysosome function and calcium mobilization, mechanisms controlling fluctuations in NAD+ levels during muscle development and regeneration, and interactions between targets of NAD+ signaling (especially mitochondria and the extracellular matrix). This knowledge should facilitate identification of more precise pharmacological and activity-based interventions to raise NAD+ levels in skeletal muscle, thereby promoting human health and function in normal and disease states.
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影响因子：
29
作者：
Frederick DW;Loro E;Liu L;Davila A Jr;Chellappa K;Silverman IM;Quinn WJ 3rd;Gosai SJ;Tichy ED;Davis JG;Mourkioti F;Gregory BD;Dellinger RW;Redpath P;Migaud ME;Nakamaru-Ogiso E;Rabinowitz JD;Khurana TS;Baur JA
通讯作者：
Baur JA
影响因子：
2.7
作者：
Goody, Michelle F.;Sher, Roger B.;Henry, Clarissa A.
通讯作者：
Henry, Clarissa A.
影响因子：
11.8
作者：
Fulco, Marcella;Cen, Yana;Sartorelli, Vittorio
通讯作者：
Sartorelli, Vittorio
DOI：
10.1016/j.bbrc.2011.06.051
发表时间：
2011-07-08
影响因子：
3.1
作者：
Cabello-Verrugio, Claudio;Jose Acuna, Maria;Brandan, Enrique
通讯作者：
Brandan, Enrique
影响因子：
3.9
作者：
Fliegert, R.;Gasser, A.;Guse, A. H.
通讯作者：
Guse, A. H.