Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.
Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.
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hsa_circ_0049224和has_circ_0049220在系统性红斑狼疮患者中的低表达及其临床价值
DOI：
10.12659/msm.906507
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发表时间：
2018-04-02
期刊：
影响因子：
--
通讯作者：
Shi W
中科院分区：
文献类型：
--
作者：
Zhang C;Huang J;Chen Y;Shi W
本研究旨在探讨两种circRNA（hsa_circ_0049224和has_circ_0049220）在SLE患者中的可能作用和临床价值。应用逆转录实时荧光聚合酶链反应（RT-PCR）检测18例SLE患者和10例健康对照者外周血单个核细胞（PBMC）中hsa_circ_0049224、has_circ_0049220和DNMT 1的表达。结果发现hsa_circ_0049224和has_circ_0049220在健康对照组中的表达均明显高于活动期和非活动期SLE患者。DNMT 1的表达水平与hsa_circ_0049224和has_circ_0049220的表达呈正相关。SLE疾病活动指数（SLEDAI）与hsa_circ_0049224和has_circ_0049220的表达呈负相关。我们还发现这两种circRNA与SLE的一些临床特征相关。Hsa_circ_0049224和has_circ_0049220可能参与了SLE的发病过程，在SLE中具有潜在的临床应用价值。
The aim of this study was to discuss the possible roles and clinical value of 2 circRNAs (hsa_circ_0049224 and has_circ_0049220) in SLE patients. Reverse-transcription real-time polymerase chain reaction (RT-PCR) was conducted to detect the expressions of hsa_circ_0049224, has_circ_0049220, and DNMT1 in peripheral blood mononuclear cells (PBMCs) from 18 diagnosed SLE patients and 10 healthy controls. We found that the expressions of hsa_circ_0049224 and has_circ_0049220 in healthy control groups were both much higher than those in inactive and active SLE patients. The expression level of DNMT1 is positively correlated with the expressions of hsa_circ_0049224 and has_circ_0049220. Moreover, there was a negative correlation between the SLE Disease Activity Index (SLEDAI) and the expressions of hsa_circ_0049224 and has_circ_0049220. We also found that these 2 circRNAs are associated with some clinical characteristics of SLE. Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE.
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