Circadian variations in plasma levels of hypophyseal, adrenocortical and testicular hormones in men infected with human immunodeficiency virus.
Circadian variations in plasma levels of hypophyseal, adrenocortical and testicular hormones in men infected with human immunodeficiency virus.
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感染人类免疫缺陷病毒的男性垂体、肾上腺皮质和睾丸激素血浆水平的昼夜变化。
DOI：
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发表时间：
1990
影响因子：
5.8
通讯作者：
F. Lévi
中科院分区：
文献类型：
--
作者：
J. Villette;P. Bourin;C. Doinel;I. Mansour;J. Fiet;P. Boudou;C. Dreux;R. Roué;M. Debord;F. Lévi
在 13 名感染人类免疫缺陷病毒 (HIV) 的男性患者中研究了几种激素分泌的昼夜时间结构的变化。 7 人无症状（根据亚特兰大疾病控制中心的标准，分类为 CDC II），6 人患有获得性免疫缺陷综合症（CDC IV）。十名健康男性自愿作为对照。第二天早上 0830-0830 点每 4 小时采集一次血样，通过 RIA 测定脱氢表雄酮 (DHEA) 及其硫酸盐 (DHEA-S)、皮质醇、睾酮、ACTH 和 β-内啡肽的血浆水平。通过双向方差分析和余弦法对数据进行分析。对三组受试者中每一种六种激素的昼夜节律进行了统计验证。与对照组相比，所有 HIV 感染者的皮质醇中值（24 小时调整平均值）显着较高，而 DHEA、DHEA-S 和 ACTH 较低（所有四种激素的 P 均小于 0.001）。对照组和 CDC II 患者的血浆睾酮中值相似，但 CDC IV 患者组的血浆睾酮中值显着下降（P 小于 0.05）。对血浆激素水平昼夜节律的分析清楚地表明，即使在感染无症状期间，艾滋病毒感染的男性患者的肾上腺激素状态也发生了改变。例如，HIV 感染者在 0430 小时时的血浆皮质醇含量是时间合格的对照组的两倍多。尽管在此阶段患者的血浆皮质醇水平已升高且肾上腺雄激素水平降低，但根据血浆睾酮浓度衡量，并未观察到性腺功能减退症。我们推测，HIV 感染者的主要激素缺陷是皮质醇分泌增加，这是由于垂体 ACTH 以外的因素对肾上腺皮质的昼夜变化刺激所致。该因子可能是主要由受感染的免疫细胞分泌的刺激物质。过量的皮质醇会通过将肾上腺类固醇生物合成转向糖皮质激素来降低肾上腺雄激素的分泌，并通过负反馈机制减少垂体 ACTH 的分泌。
Alterations in the circadian time structure of the secretion of several hormones were investigated in 13 male patients infected with human immunodeficiency virus (HIV). Seven were asymptomatic (classified CDC II, according to the criteria of the Atlanta Centers for Disease Control), and 6 had acquired immunodeficiency syndrome (CDC IV). Ten healthy males volunteered as controls. Plasma levels of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S), cortisol, testosterone, ACTH, and beta-endorphin were determined by RIA in blood samples obtained every 4 h from 0830-0830 h the next morning. Data were analyzed both by two-way analysis of variance and the cosinor method. Circadian rhythms were statistically validated for each of the six hormones in each of the three groups of subjects. Compared with the control subjects, mesors (24-h adjusted means) were significantly higher for cortisol and lower for DHEA, DHEA-S, and ACTH (P less than 0.001 for all four hormones) in all HIV-infected patients. Plasma testosterone mesors were similar in controls and CDC II patients, but decreased significantly in the CDC IV patient group (P less than 0.05). Analysis of the circadian rhythms of plasma hormone levels clearly indicated an altered adrenal hormonal state in HIV-infected male patients, even during the asymptomatic period of the infection. For instance, plasma cortisol at 0430 h was more than twice as high in HIV-infected patients as it was in time-qualified controls. Although patients already had elevated plasma cortisol and lowered adrenal androgen levels at this stage, hypogonadism was not observed, as gauged by plasma testosterone concentrations. We speculate that the primary hormonal defect in HIV-infected patients is increased cortisol secretion resulting from circadian-varying stimulation of the adrenal cortex by a factor other than pituitary ACTH. This factor might be a stimulating substance secreted primarily by infected immune cells. Excess cortisol would lower adrenal androgen secretion by shifting adrenal steroid biosynthesis toward glucocorticoids and decreasing pituitary ACTH secretion via a negative feedback mechanism.
脱氢表雄酮（DHEA）及其代谢物对肥胖高血糖突变小鼠的治疗作用。
DOI：
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发表时间：
1988
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
Coleman,DL
通讯作者：
Coleman,DL
影响因子：
5.8
作者：
NESTLER, JE;BARLASCINI, CO;BLACKARD, WG
通讯作者：
BLACKARD, WG
影响因子：
158.5
作者：
BARRETTCONNOR, E;KHAW, KT;YEN, SSC
通讯作者：
YEN, SSC